“Any response to a drug which is noxious, unintended & which occurs at dose normally
used in man for the prophylaxis, diagnosis, or therapy of disease, or for the modifications of …

Reactive oxygen species (ROS) are produced as a normal product of plant cellular
metabolism. Various environmental stresses lead to excessive production of ROS causing …

Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor
immune responses, has led to important clinical advances and provided a new weapon …

Research in two fronts has enabled the development of therapies that provide significant
benefit to cancer patients. One area stems from a detailed knowledge of mutations that activate …

Preclinical mouse models suggest that the gut microbiome modulates tumor response to
checkpoint blockade immunotherapy; however, this has not been well-characterized in human …

… The hazard ratio for death with nivolumab versus everolimus was 0.73 (98.5% CI, 0.57 to
0.93; P=0.002), which met the prespecified criterion for superiority (P≤0.0148). The objective …

… ratio for death, 0.63; P<0.001). The objective response rate was 42% versus 27% (P<0.001),
and … ratio for disease progression or death, 0.82; P=0.03, not significant per the prespecified …

INTRODUCTION Wheat (Triticum aestivum L.) is the most widely cultivated crop on Earth,
contributing about a fifth of the total calories consumed by humans. Consequently, wheat …

10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the …