Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting
therapeutic dosages of anticancer drugs and by impairing the quality of life of patients …

Background: Proton pump inhibitors (PPIs) are among the most commonly used medications
by patients due to its availability over the counter and frequent prescribing by physicians to …

Doxorubicin (DOX), an anthracycline used to treat a variety of cancers, is known to generate
intracellular reactive oxygen species. Moreover, many patients who have undergone …

The side effects of cancer therapy on normal tissues limit the success of therapy. Generation
of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic …

Purpose Aprepitant and its parenteral formulation fosaprepitant are widely used for the
prevention of chemotherapy-induced nausea and vomiting. Aprepitant exerts modest inhibitory …

Doxorubicin (DOX) is a potent chemotherapeutic agent known to cause acute and long-term
cognitive impairments in cancer patients. Cognitive function is presumed to be primarily …

We examined the effect of shared decision-making (SDM) on women’s adherence to breast
and cervical cancer screenings and estimated the prevalence and adherence rate of …

Manganese superoxide dismutase is a nuclear encoded primary antioxidant enzyme
localized exclusively in the mitochondrial matrix. Genotoxic agents, such as ultraviolet (UV) …

Multidrug resistance-associated protein 1 (Mrp1; Abcc1) is expressed in sarcolemma of
murine heart, where it probably protects the cardiomyocyte by mediating efflux of endo- and …

The clinical use of doxorubicin is limited by the total cumulative dose due to its dose-related
cardiac toxicities. Clinical manifestation of doxorubicin-mediated cardiotoxicity may be …