We evaluated the safety, pharmacokinetic profile, pharmacodynamic effects, and antitumor
activity of abemaciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDK) 4 …

Effective treatments for primary brain tumors and brain metastases represent a major unmet
medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent …

Protein kinase C (PKC), a family of serine/threonine-specific kinases, plays a key role in cell
growth, metabolism, and differentiation. 1 Because the activated enzyme has been impli-…

Clinical outcomes of vincristine therapy, both neurotoxicity and efficacy, are unpredictable,
and the reported pharmacokinetics of vincristine have considerable interindividual variability. …

Herein we demonstrate that a small panel of variants of cytochrome P450 BM3 from Bacillus
megaterium covers the breadth of reactivity of human P450s by producing 12 of 13 …

Capsaicin is a common dietary constituent and a popular homeopathic treatment for chronic
pain. Exposure to capsaicin has been shown to cause various dose-dependent acute …

Purpose: p38 MAPK regulates the production of cytokines in the tumor microenvironment
and enables cancer cells to survive despite oncogenic stress, radiotherapy, chemotherapy, …

The Pkc1-mediated cell wall integrity-signaling pathway is highly conserved in fungi and is
essential for fungal growth. We thus explored the potential of targeting the Pkc1 protein …

Signal peptidase (SPase) I is responsible for the cleavage of signal peptides of many secreted
proteins in bacteria. Because of its unique physiological and biochemical properties, it …

Background and Objectives Abemaciclib, a dual inhibitor of cyclin-dependent kinases 4 and
6, has demonstrated clinical activity in a number of different cancer types. The objectives of …