User profiles for Paolo Vicini
 | Paolo ViciniConfo Therapeutics Verified email at u.washington.edu Cited by 8377 |
SAAM II: simulation, analysis, and modeling software for tracer and pharmacokinetic studies
Kinetic analysis and integrated systems modeling have contributed substantially to our
understanding of the physiology and pathophysiology of metabolic systems and the distribution …
understanding of the physiology and pathophysiology of metabolic systems and the distribution …
Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque
Background— Neovasculature within atherosclerotic plaques is believed to be associated
with infiltration of inflammatory cells and plaque destabilization. The aim of the present …
with infiltration of inflammatory cells and plaque destabilization. The aim of the present …
[PDF][PDF] Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms
…, P Van der Graaf, P Vicini - An NIH white …, 2011 - customsitesmedia.usc.edu
Background: This white paper arises from two workshops held at the NIH in 2008 and late
2010 with participation from academia, industry and government (http://meetings. nigms. nih. …
2010 with participation from academia, industry and government (http://meetings. nigms. nih. …
alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes.
T Konrad, P Vicini, K Kusterer, A Höflich… - Diabetes …, 1999 - Am Diabetes Assoc
OBJECTIVE: We examined the effect of lipoic acid (LA), a cofactor of the pyruvate
dehydrogenase complex (PDH), on insulin sensitivity (SI) and glucose effectiveness (SG) and on …
dehydrogenase complex (PDH), on insulin sensitivity (SI) and glucose effectiveness (SG) and on …
[HTML][HTML] Catch-bond model derived from allostery explains force-activated bacterial adhesion
High shear enhances the adhesion of Escherichia coli bacteria binding to mannose coated
surfaces via the adhesin FimH, raising the question as to whether FimH forms catch bonds …
surfaces via the adhesin FimH, raising the question as to whether FimH forms catch bonds …
Why has model‐informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future
Patient groups prone to polypharmacy and special subpopulations are susceptible to
suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic …
suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic …
The hot IVGTT two-compartment minimal model: indexes of glucose effectiveness and insulin sensitivity
A two-compartment minimal model (2CMM) has been proposed [A. Caumo and C. Cobelli.Am.
J. Physiol. 264 (Endocrinol. Metab. 27): E829–E841, 1993] to describe intravenous …
J. Physiol. 264 (Endocrinol. Metab. 27): E829–E841, 1993] to describe intravenous …
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as PDL1 …
emerge, highlighted by the expression of immune checkpoint-related molecules such as PDL1 …
[HTML][HTML] Pubertal adolescent male-female differences in insulin sensitivity and glucose effectiveness determined by the one compartment minimal model
Most studies of insulin sensitivity in puberty have been cross-sectional and have not been
able to longitudinally address changes that might occur. In addition, these studies were …
able to longitudinally address changes that might occur. In addition, these studies were …
POPED, a software for optimal experiment design in population kinetics
Population kinetic analysis is the methodology used to quantify inter-subject variability in
kinetic studies. It entails the collection of (possibly sparse) data from dynamic experiments in a …
kinetic studies. It entails the collection of (possibly sparse) data from dynamic experiments in a …