The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

BE Jones, PL Brown-Augsburger, KS Corbett… - Science translational …, 2021 - science.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat
for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies …

Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure

…, RL Cain, JH Satterwhite, PL Brown-Augsburger… - Bone, 2003 - Elsevier
Parathyroid hormone (PTH)(1-34), given once daily, increases bone mass in a variety of
animal models and humans with osteoporosis. However, continuous PTH infusion has been …

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed.
Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led …

[HTML][HTML] Photoacoustic imaging reveals mechanisms of rapid-acting insulin formulations dynamics at the injection site

…, AL Cox, R Cao, J Shi, PL Brown-Augsburger… - Molecular …, 2022 - Elsevier
Objective Ultra-rapid insulin formulations control postprandial hyperglycemia; however,
inadequate understanding of injection site absorption mechanisms is limiting further …

Development of a sensitive and specific in situ hybridization technique for the cellular localization of antisense oligodeoxynucleotide drugs in tissue sections

…, VJ Wroblewski, PL Brown-Augsburger - Toxicologic …, 2007 - journals.sagepub.com
A sensitive method has been developed for the identification and assessment of phosphorothioate
oligonucleotide accumulation in dosed animal tissues using an in situ hybridization …

Disposition of basal insulin peglispro compared with 20-kDa polyethylene glycol in rats following a single intravenous or subcutaneous dose

MP Knadler, BB Ellis, PL Brown-Augsburger… - Drug Metabolism and …, 2015 - ASPET
Basal insulin peglispro (BIL) comprises insulin lispro covalently bound to a 20-kDa
polyethylene glycol (PEG) at lysine B28. The biologic fate of BIL and unconjugated PEG were …

[HTML][HTML] Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood …

…, K Maslov, PL Brown-Augsburger… - Journal of …, 2023 - spiedigitallibrary.org
Patricia L. Brown-Augsburger is an associate vice president in the Department of Drug
Disposition at Eli Lilly and Company. She received her BS degree in biochemistry from Michigan …

Correlation between antidrug antibodies, pre-existing antidrug reactivity, and immunogenetics (MHC class II alleles) in cynomolgus macaque

N Kovalova, MD Knierman, PL Brown-Augsburger… - Immunogenetics, 2019 - Springer
Immunogenicity of biomolecules is one of the largest concerns in biological therapeutic drug
development. Adverse immune responses as a result of immunogenicity to biotherapeutics …

Validation of a de‐immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human

…, DR Witcher, PL BrownAugsburger… - … & Drug Disposition, 2020 - Wiley Online Library
The immunogenicity of biotherapeutics presents a major challenge during the clinical
development of new protein drugs including monoclonal antibodies. To address this, multiple …

Photoacoustic imaging reveals transient decrease of oxygenation in murine blood due to monoclonal IgG4 antibody

…, CD Paavola, K Maslov, PL Brown-Augsburger… - bioRxiv, 2022 - biorxiv.org
Over 100 monoclonal antibodies have been approved by the FDA for clinical use; however,
a paucity of knowledge exists regarding the injection site behavior of these formulated …