Serial single-cell genomics reveals convergent subclonal evolution of resistance as patients with early-stage breast cancer progress on endocrine plus CDK4/6 …
JI Griffiths, J Chen, PA Cosgrove, A O'Dea, P Sharma… - Nature cancer, 2021 - nature.com
Combining cyclin-dependent kinase (CDK) inhibitors with endocrine therapy improves
outcomes for patients with metastatic estrogen receptor-positive breast cancer but its value in …
outcomes for patients with metastatic estrogen receptor-positive breast cancer but its value in …
Modeling therapeutic antibody–small molecule drug-drug interactions using a three-dimensional perfusable human liver coculture platform
TJ Long, PA Cosgrove, RT Dunn, DB Stolz… - Drug Metabolism and …, 2016 - ASPET
Traditional in vitro human liver cell culture models lose key hepatic functions such as
metabolic activity during short-term culture. Advanced three-dimensional (3D) liver coculture …
metabolic activity during short-term culture. Advanced three-dimensional (3D) liver coculture …
Circulating immune cell phenotype dynamics reflect the strength of tumor–immune cell interactions in patients during immunotherapy
…, D Stenehjem, X Liu, PA Cosgrove… - Proceedings of the …, 2020 - National Acad Sciences
The extent to which immune cell phenotypes in the peripheral blood reflect within-tumor
immune activity prior to and early in cancer therapy is unclear. To address this question, we …
immune activity prior to and early in cancer therapy is unclear. To address this question, we …
[HTML][HTML] Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer
The evolution of resistance in high-grade serous ovarian cancer (HGSOC) cells following
chemotherapy is only partially understood. To understand the selection of factors driving …
chemotherapy is only partially understood. To understand the selection of factors driving …
[HTML][HTML] Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model
VK Grolmusz, J Chen, R Emond, PA Cosgrove… - Cancer cell …, 2020 - Springer
Background CDK4/6 inhibitors such as ribociclib are becoming widely used targeted therapies
in hormone-receptor-positive (HR+) human epidermal growth factor receptor 2-negative (…
in hormone-receptor-positive (HR+) human epidermal growth factor receptor 2-negative (…
[HTML][HTML] RAGE inhibitors as alternatives to dexamethasone for managing cerebral edema following brain tumor surgery
Resection of brain tumors frequently causes injury to the surrounding brain tissue that
exacerbates cerebral edema by activating an inflammatory cascade. Although corticosteroids are …
exacerbates cerebral edema by activating an inflammatory cascade. Although corticosteroids are …
Protecting crew and surface systems with a long-duration lunar safe haven
ML Grande, RW Moses, PA Cosgrove, RP Mueller… - ASCEND 2021, 2021 - arc.aiaa.org
View Video Presentation: https://doi.org/10.2514/6.2021-4070.vid NASA’s Artemis program
will send astronauts to the lunar surface for extended mission durations throughout the 2030s…
will send astronauts to the lunar surface for extended mission durations throughout the 2030s…
ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
…, R Emond, KL Karimi, VK Grolmusz, PA Cosgrove… - Elife, 2023 - elifesciences.org
The mTOR inhibitor, everolimus, is an important clinical management component of metastatic
ER+ breast cancer (BC). However, most patients develop resistance and progress on …
ER+ breast cancer (BC). However, most patients develop resistance and progress on …
[HTML][HTML] A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice
…, JR Turk, J Lawrence, PA Cosgrove… - Lipids in health and …, 2014 - Springer
Background Previously, we identified three loci affecting HDL-cholesterol levels in a screen
for ENU-induced mutations in mice and discovered two mutated genes. We sought to identify …
for ENU-induced mutations in mice and discovered two mutated genes. We sought to identify …
[HTML][HTML] Aone-two punch'therapy strategy to target chemoresistance in estrogen receptor positive breast cancer
Cancer cell phenotypes evolve during a tumor's treatment. In some cases, tumor cells
acquire cancer stem cell-like (CSL) traits such as resistance to chemotherapy and diminished …
acquire cancer stem cell-like (CSL) traits such as resistance to chemotherapy and diminished …