[HTML][HTML] Bidirectional transport of amino acids regulates mTOR and autophagy

P Nicklin, P Bergman, B Zhang, E Triantafellow… - Cell, 2009 - cell.com
Amino acids are required for activation of the mammalian target of rapamycin (mTOR) kinase
which regulates protein translation, cell growth, and autophagy. Cell surface transporters …

Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension

…, RC Trembath, S Jennings, L Barker, P Nicklin… - Circulation, 2010 - Am Heart Assoc
Background— Inflammation is a feature of pulmonary arterial hypertension (PAH), and
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …

Second generation of antisense oligonucleotides: from nuclease resistance to biological efficacy in animals

…, P Martin, BP Monia, M Müller, F Natt, P Nicklin… - Chimia, 1996 - chimia.ch
From efforts to improve the biophysical properties of antisense oligonucleotides by incorporating
backbone-or sugar-modified nucleoside analogs, 2'-O-methoxyethyl ribonucleosides …

Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions

RA Stringer, C Strain-Damerell, P Nicklin… - Drug Metabolism and …, 2009 - ASPET
The aim of this study was to explore the potential of recombinant cytochrome P450 (P450)
enzymes for human metabolic clearance prediction. The relative abundance and relative …

Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression

…, L Miraglia, R Howard, S Cooper, J Giddings, P Nicklin… - Cancer Research, 1996 - AACR
A 20-mer phosphorothioate oligodeoxynucleotide (ISIS 3521) designed to hybridize sequences
in the 3′-untranslated region of human protein kinase C-α (PKC-α) mRNA has been …

FKBP51 modulates steroid sensitivity and NFκB signalling: a novel anti‐inflammatory drug target

…, T Bretschneider, D Lamb, P Nicklin… - European journal of …, 2018 - Wiley Online Library
Steroid refractory inflammation is an unmet medical need in the management of inflammatory
diseases. Thus, mechanisms, improving steroid sensitivity and simultaneously decreasing …

Screening for YAP inhibitors identifies statins as modulators of fibrosis

…, Y Lin, M Bieler, P Seither, P Nicklin… - American Journal of …, 2020 - atsjournals.org
Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized
by pathological fibroblast activation and aberrant lung remodeling with scar formation…

[HTML][HTML] Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis

…, A Holweg, M Schuler, M Frick, P Nicklin… - Respiratory …, 2019 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by
aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the …

Discovery of BI-2545: A novel autotaxin inhibitor that significantly reduces LPA levels in vivo

…, B Nosse, H Romig, P Nicklin… - ACS Medicinal …, 2017 - ACS Publications
In an effort to find new therapeutic interventions addressing the unmet medical need of
patients with idiopathic pulmonary fibrosis, we initiated a program to identify new autotaxin (ATX) …

opnMe. com: a digital initiative for sharing tools with the biomedical research community

A Gollner, M Köster, P Nicklin, T Trieselmann… - Nature Reviews Drug …, 2022 - nature.com
Pharmacological probes are important tools for exploring disease biology and discovering
new therapies. Often molecules of insufficient quality are used instead, leading to spurious …