[HTML][HTML] Bidirectional transport of amino acids regulates mTOR and autophagy
P Nicklin, P Bergman, B Zhang, E Triantafellow… - Cell, 2009 - cell.com
Amino acids are required for activation of the mammalian target of rapamycin (mTOR) kinase
which regulates protein translation, cell growth, and autophagy. Cell surface transporters …
which regulates protein translation, cell growth, and autophagy. Cell surface transporters …
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension
…, RC Trembath, S Jennings, L Barker, P Nicklin… - Circulation, 2010 - Am Heart Assoc
Background— Inflammation is a feature of pulmonary arterial hypertension (PAH), and
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …
Second generation of antisense oligonucleotides: from nuclease resistance to biological efficacy in animals
…, P Martin, BP Monia, M Müller, F Natt, P Nicklin… - Chimia, 1996 - chimia.ch
From efforts to improve the biophysical properties of antisense oligonucleotides by incorporating
backbone-or sugar-modified nucleoside analogs, 2'-O-methoxyethyl ribonucleosides …
backbone-or sugar-modified nucleoside analogs, 2'-O-methoxyethyl ribonucleosides …
Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions
RA Stringer, C Strain-Damerell, P Nicklin… - Drug Metabolism and …, 2009 - ASPET
The aim of this study was to explore the potential of recombinant cytochrome P450 (P450)
enzymes for human metabolic clearance prediction. The relative abundance and relative …
enzymes for human metabolic clearance prediction. The relative abundance and relative …
Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression
…, L Miraglia, R Howard, S Cooper, J Giddings, P Nicklin… - Cancer Research, 1996 - AACR
A 20-mer phosphorothioate oligodeoxynucleotide (ISIS 3521) designed to hybridize sequences
in the 3′-untranslated region of human protein kinase C-α (PKC-α) mRNA has been …
in the 3′-untranslated region of human protein kinase C-α (PKC-α) mRNA has been …
FKBP51 modulates steroid sensitivity and NFκB signalling: a novel anti‐inflammatory drug target
…, T Bretschneider, D Lamb, P Nicklin… - European journal of …, 2018 - Wiley Online Library
Steroid refractory inflammation is an unmet medical need in the management of inflammatory
diseases. Thus, mechanisms, improving steroid sensitivity and simultaneously decreasing …
diseases. Thus, mechanisms, improving steroid sensitivity and simultaneously decreasing …
Screening for YAP inhibitors identifies statins as modulators of fibrosis
…, Y Lin, M Bieler, P Seither, P Nicklin… - American Journal of …, 2020 - atsjournals.org
Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized
by pathological fibroblast activation and aberrant lung remodeling with scar formation…
by pathological fibroblast activation and aberrant lung remodeling with scar formation…
[HTML][HTML] Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
…, A Holweg, M Schuler, M Frick, P Nicklin… - Respiratory …, 2019 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by
aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the …
aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the …
Discovery of BI-2545: A novel autotaxin inhibitor that significantly reduces LPA levels in vivo
…, B Nosse, H Romig, P Nicklin… - ACS Medicinal …, 2017 - ACS Publications
In an effort to find new therapeutic interventions addressing the unmet medical need of
patients with idiopathic pulmonary fibrosis, we initiated a program to identify new autotaxin (ATX) …
patients with idiopathic pulmonary fibrosis, we initiated a program to identify new autotaxin (ATX) …
opnMe. com: a digital initiative for sharing tools with the biomedical research community
A Gollner, M Köster, P Nicklin, T Trieselmann… - Nature Reviews Drug …, 2022 - nature.com
Pharmacological probes are important tools for exploring disease biology and discovering
new therapies. Often molecules of insufficient quality are used instead, leading to spurious …
new therapies. Often molecules of insufficient quality are used instead, leading to spurious …