A new pharmacological class of CNS ligands with the unique ability to stimulate or suppress
motor and behavioral symptoms depending on the prevailing dopaminergic tone has been …

Ticagrelor is a direct-acting reversibly binding P2Y 12 antagonist and is widely used as an
antiplatelet therapy for the prevention of cardiovascular events in acute coronary syndrome …

Zebrafish is emerging as a complement to mammals in behavioral studies; however, there
is a lack of comparative studies with rodents and humans to establish the zebrafish as a …

Structure-property relationships, central to many of today's drug discovery strategies, are not
straightforward to deal with when trying to predict drug efficacy, that is, the combined …

Oxetane-containing ring systems are increasingly used in medicinal chemistry programs to
modulate druglike properties. We have shown previously that oxetanes are hydrolyzed to …

Thrombin is an essential protein involved in blood clot formation and an important clinical
target, since disturbances of the coagulation process cause serious cardiovascular diseases …

The potential energy surface (PES) of C9H9+ has been exploredin the region of the 9-barbaralyl
cation (3) at MP2/-, MP3/-, and MP4 (SDQ)/6-3 lG (d). Calculations show that 3 is 6.9 …

IRL790 ([2-(3-fluoro-5-methanesulfonylphenoxy)ethyl](propyl)amine, mesdopetam) is a
novel compound in development for the clinical management of motor and psychiatric …

This study is focused on the identification of structural features that determine the selectivity
of dopamine receptor agonists toward D 1 and D 2 receptors. Selective pharmacophore …

A series of 6-substituted 3-(pyrrolidin-1-ylmethyl)chromen-2-ones (coumarins) have been
synthesized and their inhibitory activity to human monoamine oxidase A (MAO A) and B (MAO …