As an important reversible lipid modification, S-palmitoylation mainly occurs at specific
cysteine residues in proteins, participates in regulating various biological processes and is …

This review summarizes state-of-the-art knowledge on fast-responding pressure-sensitive
paint (fast PSP), which has evolved into a powerful experimental tool for studying complex …

Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced
cancer, but its biological basis has remained obscure. We demonstrate here a molecular …

As an important post-translational modification (PTM), protein phosphorylation is involved in
the regulation of almost all of biological processes in eukaryotes. Due to the rapid progress …

Although treatment with immune checkpoint inhibitors provides promising benefit for patients
with cancer, optimal use is encumbered by high resistance rates and requires a thorough …

Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired,
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …

In eukaryotes, protein phosphorylation is specifically catalyzed by numerous protein kinases
(PKs), faithfully orchestrates various biological processes, and reversibly determines …

Breast cancer is a major health threat for women. The drug responses associated with
different breast cancer subtypes have obvious effects on therapeutic outcomes; therefore, the …

Identifying disease-causing variants among a large number of single nucleotide variants (SNVs)
is still a major challenge. Recently, N 6 -methyladenosine (m 6 A) has become a …

Various posttranslational modifications (PTMs) participate in nearly all aspects of biological
processes by regulating protein functions, and aberrant states of PTMs are frequently …