Although ionic liquids are generally referred to in a ‘green’ context, little is known about their
degradation in the environment. Part I of this series focused on the biodegradability of the …

Specifically designed bivalent ligands targeting G protein‐coupled receptor (GPCR) dimeric
structures have become increasingly popular in recent literature. The advantages of the …

Historically, determination of G protein‐coupled receptor (GPCR) ligand efficacy has often
been restricted to identifying the ligand as an agonist or antagonist at a given signaling …

The design, preparation and evaluation of biodegradable ionic liquids containing ester or
amide groups in the alkyl side chain are presented. Factors improving the biodegradation of …

Further research toward the discovery of biodegradable ionic liquids (ILs) is described
herein. The biodegradability of the target ILs was evaluated using the ‘Closed Bottle’ and ‘CO2 …

There has been an explosion of interest in ionic liquids in the last five years that has resulted
in the discovery of a vast number of new ionic liquids with a wide range of interesting …

Biased agonism describes the ability of ligands to stabilize different conformations of a
GPCR linked to distinct functional outcomes and offers the prospect of designing pathway-specific …

The adenosine A 1 receptor (A 1 -AR) is a G-protein-coupled receptor that plays a vital role
in cardiac, renal, and neuronal processes but remains poorly targeted by current drugs. We …

A range of ionic liquids (ILs) with a pyridinium cation were synthesised and their biodegradability
was evaluated using the CO2 Headspace test (ISO 14593). ILs bearing an ester side …

Many G protein-coupled receptors (GPCRs) possess allosteric binding sites distinct from the
orthosteric site utilized by their cognate ligands, but most GPCR allosteric modulators …