User profiles for Peter Olinga
 | Peter OlingaProfessor of Translational Biopharmaceutics, University of Groningen Verified email at rug.nl Cited by 9364 |
Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies
IAM De Graaf, P Olinga, MH De Jager, MT Merema… - Nature protocols, 2010 - nature.com
Precision-cut tissue slices (PCTS) are viable ex vivo explants of tissue with a reproducible,
well defined thickness. They represent a mini-model of the organ under study and contain all …
well defined thickness. They represent a mini-model of the organ under study and contain all …
Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats
BN Melgert, P Olinga, JMS Van Der Laan, B Weert… - Hepatology, 2001 - journals.lww.com
Kupffer cells (KC) play an important role in the pathogenesis of inflammatory liver diseases
leading to fibrosis. Anti-inflammatory drugs are only effective when administered at high …
leading to fibrosis. Anti-inflammatory drugs are only effective when administered at high …
Precision-cut tissue slices as a tool to predict metabolism of novel drugs
IAM Graaf, GMM Groothuis, P Olinga - Expert opinion on drug …, 2007 - Taylor & Francis
Precision-cut tissue slices have been applied by many researchers because they represent
an organ mini-model that closely resembles the organ from which it is prepared, with all cell …
an organ mini-model that closely resembles the organ from which it is prepared, with all cell …
Production methods and stabilization strategies for polymer-based nanoparticles and microparticles for parenteral delivery of peptides and proteins
Introduction: Therapeutic proteins and peptides often require parenteral administration,
which compels frequent administration and patient discomfort. This ultimately decreases …
which compels frequent administration and patient discomfort. This ultimately decreases …
[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
Procalcitonin behaves as a fast responding acute phase proteinin vivoandin vitro
Objectives: Procalcitonin (PCT) is a 13 kD protein of which plasma concentrations are
strongly increased in inflammatory states. PCT concentrations are claimed to have a more …
strongly increased in inflammatory states. PCT concentrations are claimed to have a more …
Targeting oxidative stress for the treatment of liver fibrosis
…, HAM Mutsaers, GMM Groothuis, P Olinga… - Reviews of Physiology …, 2018 - Springer
Oxidative stress is a reflection of the imbalance between the production of reactive oxygen
species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS, …
species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS, …
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process
MGL Elferink, P Olinga, AL Draaisma… - American Journal …, 2004 - journals.physiology.org
Endotoxin-induced cholestasis in rodents is caused by hepatic downregulation of transporters,
including the basolateral Na + -dependent taurocholate transporter (ntcp) and the …
including the basolateral Na + -dependent taurocholate transporter (ntcp) and the …
Albumin Modified With Mannose 6–Phosphate: A Potential Carrier for Selective Delivery of Antifibrotic Drugs to Rat and Human Hepatic Stellate Cells
The hallmark of liver fibrosis is an increased extracellular matrix deposition, caused by an
activation of hepatic stellate cells (HSC). Therefore, this cell type is an important target for …
activation of hepatic stellate cells (HSC). Therefore, this cell type is an important target for …
[PDF][PDF] Precision-cut liver slices: a tool to model the liver ex vivo
P Olinga, D Schuppan - Journal of hepatology, 2013 - research.rug.nl
… Olinga@rug.nl … [5] Westra IM, Pham BT, Groothuis GM, Olinga P. Evaluation of fibrosis
in precision-cut tissue slices. Xenobiotica 2013;43:98–112. … [10] van de Bovenkamp M …
in precision-cut tissue slices. Xenobiotica 2013;43:98–112. … [10] van de Bovenkamp M …