The comprehensive antibiotic resistance database

…, LJV Piddock, P Spanogiannopoulos… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The field of antibiotic drug discovery and the monitoring of new antibiotic resistance elements
have yet to fully exploit the power of the genome revolution. Despite the fact that the first …

The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism

P Spanogiannopoulos, EN Bess… - Nature Reviews …, 2016 - nature.com
Although the importance of human genetic polymorphisms in therapeutic outcomes is well
established, the role of our 'second genome' (the microbiome) has been largely overlooked. In …

Caloric restriction disrupts the microbiota and colonization resistance

…, JE Bisanz, S Lyalina, P Spanogiannopoulos… - Nature, 2021 - nature.com
Diet is a major factor that shapes the gut microbiome 1 , but the consequences of diet-induced
changes in the microbiome for host pathophysiology remain poorly understood. We …

The tetracycline resistome

M Thaker, P Spanogiannopoulos, GD Wright - Cellular and Molecular Life …, 2010 - Springer
Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical
and non-clinical uses of this class of antibiotic over the years have combined to select for …

Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism

P Spanogiannopoulos, TS Kyaw, BGH Guthrie… - Nature …, 2022 - nature.com
Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether
bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells …

Identifying producers of antibacterial compounds by screening for antibiotic resistance

MN Thaker, W Wang, P Spanogiannopoulos… - Nature …, 2013 - nature.com
Microbially derived natural products are major sources of antibiotics and other medicines, but
discovering new antibiotic scaffolds and increasing the chemical diversity of existing ones …

[PDF][PDF] Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

KN Lam, P Spanogiannopoulos, P Soto-Perez… - Cell Reports, 2021 - cell.com
Mechanistic insights into the role of the human microbiome in the predisposition to and
treatment of disease are limited by the lack of methods to precisely add or remove microbial …

Cooking shapes the structure and function of the gut microbiome

…, V Maini Rekdal, EN Bess, P Spanogiannopoulos… - Nature …, 2019 - nature.com
Diet is a critical determinant of variation in gut microbial structure and function, outweighing
even host genetics 1 , 2 – 3 . Numerous microbiome studies have compared diets with …

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria

…, QY Ang, DL Alba, P Spanogiannopoulos… - Nature …, 2020 - nature.com
Plant-derived lignans, consumed daily by most individuals, are thought to protect against
cancer and other diseases 1 ; however, their bioactivity requires gut bacterial conversion to …

A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria

P Spanogiannopoulos, N Waglechner… - Proceedings of the …, 2014 - National Acad Sciences
Many environmental bacteria are multidrug-resistant and represent a reservoir of ancient
antibiotic resistance determinants, which have been linked to genes found in pathogens. …