Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults

…, AD Hutson, RH Eckel, PW Stacpoole - Diabetes …, 2003 - Am Diabetes Assoc
OBJECTIVE—To determine the effects of exercise, without weight loss, on insulin sensitivity
(S I ), postheparin plasma lipase activity (PHPL), intravenous fat clearance rate (K 2 ), and …

The pharmacology of dichloroacetate

PW Stacpoole - Metabolism, 1989 - Elsevier
Dichloroacetate (DCA) exerts multiple effects on pathways of intermediary metabolism. It
stimulates peripheral glucose utilization and inhibits gluconeogeneis, thereby reducing …

[HTML][HTML] A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults

PW Stacpoole, EC Wright… - … England Journal of …, 1992 - Mass Medical Soc
Background. Mortality is very high in lactic acidosis, and there is no satisfactory treatment
other than treatment of the underlying cause. Uncontrolled studies have suggested that …

The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients

…, SH Subramony, J Shuster, PW Stacpoole - Molecular genetics and …, 2012 - Elsevier
CONTEXT: Pyruvate dehydrogenase complex (PDC) deficiency is a genetic mitochondrial
disorder commonly associated with lactic acidosis, progressive neurological and …

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

PW Stacpoole, DS Kerr, C Barnes, ST Bunch… - …, 2006 - publications.aap.org
OBJECTIVE. Open-label studies indicate that oral dichloroacetate (DCA) may be effective in
treating patients with congenital lactic acidosis. We tested this hypothesis by conducting the …

Therapeutic targeting of the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis in cancer

PW Stacpoole - JNCI: Journal of the National Cancer Institute, 2017 - academic.oup.com
The mitochondrial pyruvate dehydrogenase complex (PDC) irreversibly decarboxylates
pyruvate to acetyl coenzyme A, thereby linking glycolysis to the tricarboxylic acid cycle and …

Nutrition principles for the management off diabetes and related complications

…, RR Henry, BJ Hoogwerf, PW Stacpoole - Diabetes …, 1994 - Am Diabetes Assoc
Health professionals and people with diabetes recognize nutrition therapy as one of the
most challenging aspects of diabetes care and education (1). Adherence to meal planning …

Dichloroacetate and cancer: new home for an orphan drug?

S Kankotia, PW Stacpoole - Biochimica et Biophysica Acta (BBA)-Reviews …, 2014 - Elsevier
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational
treatment for various acquired and congenital disorders of mitochondrial intermediary …

[HTML][HTML] Patient care standards for primary mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

…, RP Saneto, F Scaglia, J Shoffner, PW Stacpoole… - Genetics in …, 2017 - Elsevier
The purpose of this statement is to provide consensus-based recommendations for optimal
management and care for patients with primary mitochondrial disease. This statement is …

Natural history and course of acquired lactic acidosis in adults

PW Stacpoole, EC Wright, TG Baumgartner… - The American journal of …, 1994 - Elsevier
study objective: To determine the pathogenesis and clinical course of lactic acidosis in adults
receiving standard medical care. design: Placebo arm of a 5-year prospective, randomized…