Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid

…, H Yeo, O Vilenski, PE Weller, PD Worboys… - Drug metabolism and …, 2009 - ASPET
The objective of the present study was to examine the accuracy of using unbound brain
concentration determined by a brain homogenate method (C ub ), cerebral spinal fluid …

Kinetics of drug metabolism in rat liver slices: III. Relationship between metabolic clearance and slice uptake rate

PD Worboys, A Bradbury, JB Houston - Drug metabolism and disposition, 1997 - ASPET
The time course for distribution of five compounds (caffeine, tolbutamide, phenytoin,
ondansetron, and diazepam) was studied in precision-cut rat liver slices. Transport of these …

Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes.

PD Worboys, A Bradbury, JB Houston - Drug metabolism and disposition, 1996 - ASPET
The kinetics of metabolism of diazepam, phenytoin, and caffeine have been determined in
rat liver slices of 260 microns thickness. The formation of 4'-hydroxy metabolites of diazepam …

[HTML][HTML] Pharmacokinetics of intravenous telavancin in healthy subjects with varying degrees of renal impairment

PD Worboys, SL Wong, SL Barriere - European Journal of Clinical …, 2015 - Springer
Purpose We evaluated the effect of renal impairment (RI) on the pharmacokinetics of telavancin
and hydroxypropylbetadex (excipient in the telavancin drug product). Methods Adults …

Kinetics of drug metabolism in rat liver slices. Rates of oxidation of ethoxycoumarin and tolbutamide, examples of high-and low-clearance compounds.

PD Worboys, A Bradbury, JB Houston - Drug Metabolism and Disposition, 1995 - ASPET
Ethoxycoumarin (EC) and tolbutamide (TOL) were selected as examples of high- and low-clearance
drugs, respectively, to investigate suitable methodologies for obtaining kinetic data …

Long‐term control of Phytophthora diseases of cocoa using trunk‐injected phosphonate

…, HJ Foard, D Phillips, S Worboys… - Plant …, 1994 - Wiley Online Library
Pod rot and stem canker, caused by Phytophthora palmivora, are serious diseases of cocoa
causing pod losses of up to 63% and the death of up to 10% of trees annually on Kar Kar …

[BOOK][B] The Utility of Liver Slices for the Prediction of Metabolic Clearance

PD Worboys - 1995 - search.proquest.com
This thesis investigates the ability of rat liver slices to metabolise drugs and predict in vivo
metabolic intrinsic clearance (CLint). Six probe substrates, tolbutamide, ethoxycoumarin, …

Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration

…, J Sinclair, A Van Weverwijk, JD Worboys… - Science …, 2016 - science.org
The exit of metastasizing tumor cells from the vasculature, extravasation, is regulated by their
dynamic interactions with the endothelial cells that line the internal surface of vessels. To …

Sidegroup dependence of chromism in polydiacetylenes

AJ Brown, G Rumbles, D Phillips, D Bloor - Chemical physics letters, 1988 - Elsevier
The absorption, fluorescence excitation and dispersed emission spectra of a family of
polydiacetylenes in solution are compared in order to elucidate the structure of several forms of …

Vague cognitive regions in geography and geographic information science

…, A Friedman, DW Phillips - International Journal of …, 2014 - Taylor & Francis
Cognitive regions are regions in the mind, reflecting informal ways individuals and cultural
groups organize their understanding of earth landscapes. Cognitive region boundaries are …