CP-809,101 is a potent, functionally selective 5-HT 2C agonist that displays approximately
100% efficacy in vitro. The aim of the present studies was to assess the efficacy of a selective …

In this communication, we wish to describe the discovery of a novel series of 6-azauracil-based
thyromimetics that possess up to 100-fold selectivities for binding and functional …

2-(3-Chlorobenzyloxy)-6-(piperazin-1-yl)pyrazine (3) is a potent and selective 5-HT 2C agonist
that exhibits dose-dependent inhibition of food intake and reduction in body weight in rats…

The compound L-660,631 (2-oxo-5-(1-hydroxy-2,4,6-heptatriynyl)-1,3-dioxolane-4 heptanoic
acid), a natural product isolated from an Actinomycete culture, was found to inhibit rat liver …

Brain-penetrable proline amides were developed as 5HT2c agonists with more than 1000-fold
binding selectivity against 5HT2b receptor. After medicinal chemistry optimization and …

Advances in molecular biology and pharmacology have led to the identification of fourteen 5-hydroxytryptamine
(serotonin, 5-HT) receptor subtypes (Hoyer et al., 2002). These subtypes …

Psychological stress during childhood and adolescence increases risk of health problems
across the lifecourse, and inflammation is implicated as an underlying mechanism. To …

The central dogma of mammalian brain sexual differentiation has contended that sex steroids
of gonadal origin organize the neural circuits of the developing brain [1]. Recent evidence …

Cardiovascular diseases are patterned by race and socioeconomic status, and chronic low-grade
inflammation is proposed as a key underlying mechanism. Theories for how racial and …

Objective: Socioeconomic disadvantage during childhood and adolescence is associated
with higher risk for many physical health problems, including infectious disease, throughout …