Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase
P Lautala, I Ulmanen, J Taskinen - Molecular pharmacology, 2001 - ASPET
Molecular mechanisms determining the turn-over rate and specificity of catechol O-methylation
were studied by combining enzyme kinetic measurements, computational modeling of …
were studied by combining enzyme kinetic measurements, computational modeling of …
The specificity of glucuronidation of entacapone and tolcapone by recombinant human UDP-glucuronosyltransferases
P Lautala, BT Ethell, J Taskinen, B Burchell - Drug Metabolism and …, 2000 - ASPET
The COMT inhibitors entacapone and tolcapone are rapidly metabolized in vivo, mainly by
glucuronidation. In this work, the main UGT isoforms responsible for their glucuronidation in …
glucuronidation. In this work, the main UGT isoforms responsible for their glucuronidation in …
Characterization of 1‐Hydroxypyrene as a Novel Marker Substrate of 3‐Methylcholanthrene‐Inducible Phenol UDP‐Glucuronosyltransferase (s)
L Luukkanen, E Elovaara, P Lautala… - Pharmacology & …, 1997 - Wiley Online Library
Rats were treated with acetone, pyrazole, phenobarbital, 4,4′‐methylenebis‐(2‐chloroaniline)
(MOCA), 3‐methylcholanthrene, creosote oil, or a mixture of polychlorinated biphenyls (…
(MOCA), 3‐methylcholanthrene, creosote oil, or a mixture of polychlorinated biphenyls (…
Glucuronidation of entacapone, nitecapone, tolcapone, and some other nitrocatechols by rat liver microsomes
P Lautala, M Kivimaa, H Salomies, E Elovaara… - Pharmaceutical …, 1997 - Springer
Purpose. Nitrocatechol COMT inhibitors are a new class of bioactive compounds, for which
glucuronidation is the most important metabolic pathway. The objective was to characterize …
glucuronidation is the most important metabolic pathway. The objective was to characterize …
Radiochemical high-performance liquid chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates
P Lautala, I Ulmanen, J Taskinen - Journal of chromatography B …, 1999 - Elsevier
A new chromatographic catechol O-methyltransferase (COMT) assay based on S-adenosyl-l-[methyl-
14 C]methionine and on-line radioactivity detection was developed. With minor …
14 C]methionine and on-line radioactivity detection was developed. With minor …
Production of human UDP-glucuronosyltransferases 1A6 and 1A9 using the Semliki Forest virus expression system
T Forsman, P Lautala, K Lundström, K Monastyrskaia… - Life sciences, 2000 - Elsevier
Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki
Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with …
Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with …
[PDF][PDF] Catechol O-Methyltransferase: Glucuronidation of Inhibitors and Methylation of Substrates
P Lautala - 2000 - Citeseer
Catechol structures can be found in many endogenous compounds including catecholamines
and catechol estrogens and in various drugs and drug candidates. Catecholic hydroxyls …
and catechol estrogens and in various drugs and drug candidates. Catecholic hydroxyls …
Use of vitamin D supplements during infancy in an international feeding trial
…, H Haavisto, S Tenhola, P Lautala… - Public health …, 2014 - cambridge.org
ObjectiveTo examine the use of vitamin D supplements during infancy among the participants
in an international infant feeding trial.DesignLongitudinal study.SettingInformation about …
in an international infant feeding trial.DesignLongitudinal study.SettingInformation about …
Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial
…, H Haavisto, S Tenhola, P Lautala… - Maternal & child …, 2017 - Wiley Online Library
Differences in breastfeeding, other milk feeding and complementary feeding patterns were
evaluated in infants at increased genetic risk with and without maternal type 1 diabetes (T1D). …
evaluated in infants at increased genetic risk with and without maternal type 1 diabetes (T1D). …
High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5′-diphosphate …
S Kaivosaari, JS Salonen, J Mortensen… - Analytical …, 2001 - Elsevier
… The authors are grateful to Pia Lautala for her advice and fruitful discussion, and to Tiina …
Lautala, P., Kivimaa, M., Salomies, H., Elovaara, E., and Taskinen, J. (1997) Pharm. Res. …
Lautala, P., Kivimaa, M., Salomies, H., Elovaara, E., and Taskinen, J. (1997) Pharm. Res. …