We demonstrate that intestinal inflammation caused by high-fat diet is increased by the
environmental contaminant benzo[a]pyrene. Our in vivo results indicate that a high-fat diet (HFD) …

The effect of cigarette smoke on the expression of several cytochromes P450 (CYP) and
UDP‐glucuronosyltransferases (UGT) was studied in mice. The animals were exposed to …

Bupivacaine is used to provide prolonged anesthesia and postoperative analgesia. The
human cytochrome P450 (CYP) involved in bupivacaine degradation into pipecolylxylidine (PPX…

This in vitro study was conducted to evaluate propofol glucuronidation and the effect of
concomitantly administered drugs in various species. Propofol glucuronidation was studied in …

Cigarette smoking is a worldwide health problem and is the greatest risk factor for lung cancer.
By activating procarcinogens, hepatic and extrahepatic cytochromes P450 can participate …

CYP1A1 isoform is mainly regulated by the transcription factor AhR and to a lesser extent by
the nuclear receptor RAR. The effect of a coexposure with 3MC, a AhR ligand, and RA, a …

In this work we demonstrate that Caco-2 cell treatment with WY-14643 (a potent PPARα
agonist) causes an increase in AhR expression. Luciferase assays and directed mutagenesis …

CYP1A1 is an extrahepatic enzyme largely involved in the bioactivation of various
procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) and arylamines. CYP1A1 …

Background We previously showed that blood serum induced cytochrome P450 1A1 (CYP1A1)
monooxygenase expression in vitro. Objective Our purpose was (i) to identify the …

Epidemiological studies have associated environmental exposure to polychlorinated
biphenyls (PCBs) with an increased risk of type 2 diabetes; however, little is known about the …