MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation
of gene expression. Evidence accumulating in the past decades indicate that they are …

We identify a new enzymatic activity underlying metastasis in breast cancer and describe its
susceptibility to therapeutic inhibition. We show that human prune (h-prune), a …

Background & Aims Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new
therapeutic agents are needed. We performed a screen to identify small-molecule compounds …

Objective Transcribed-ultraconserved regions (T-UCR) are long non-coding RNAs which
are conserved across species and are involved in carcinogenesis. We studied T-UCRs …

Pancreatic cancer is an aggressive cancer of the digestive system, which is becoming a
serious health problem worldwide. Overall survival for patients with pancreatic cancer is poor, …

The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed
more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and …

Although biliary tract cancers (BTCs) are known to have an inflammatory component, a
detailed characterisation of immune-related transcripts has never been performed. In these …

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide.
Despite recent therapeutic advancements, resistance to 5-fluorouracil (5-FU) remains a major …

Background and Aims Changes in single microRNA (miRNA) expression have been associated
with chemo‐resistance in biliary tract cancers (BTCs). However, a global assessment of …

Vandetanib is an oral inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2),
epidermal growth factor receptor (EGFR) and Ret tyrosine kinases involved in tumor growth, …