Human liver CYP2E1 is a monotopic, endoplasmic reticulum-anchored cytochrome P450
responsible for the biotransformation of clinically relevant drugs, low molecular weight …

Finding an antibody that works for a specific application can be a difficult task. Hundreds of
vendors offer millions of antibodies, but the quality of these products and available validation …

A robust screen for compound interaction with P-glycoprotein (P-gp) has some obvious
requirements, such as a cell line expressing P-gp and a probe substrate that is transported solely …

Cytochromes P450 (P450s) incur phosphorylation. Although the precise role of this post-translational
modification is unclear, marking P450s for degradation is plausible. Indeed, we …

CYP3A4, an integral endoplasmic reticulum (ER)-anchored protein, is the major human liver
cytochrome P450 enzyme responsible for the disposition of over 50% of clinically relevant …

We have reported previously that the hepatic heme-regulated inhibitor (HRI)-eukaryotic
initiation factor 2α (eIF2α) kinase is activated in acute heme-deficient states, resulting in …

CYP3A4 is a dominant human liver cytochrome P450 enzyme engaged in the metabolism
and disposition of >50% of clinically relevant drugs and held responsible for many adverse …

Hepatic cytochromes P450 3A (P450s 3A) are endoplasmic reticulum (ER)-proteins,
responsible for xenobiotic metabolism. They are degraded by the ubiquitin-dependent 26S …

The CYP3A subfamily of hepatic cytochromes P450, being engaged in the metabolism and
clearance of >50% of clinically relevant drugs, can significantly influence therapeutics and …

The multidrug resistance transporter P-glycoprotein (P-gp) effluxes a wide range of substrates
and can be affected by a wide range of inhibitors or modulators. Many studies have …