Isobaric labeling empowers proteome-wide expression measurements simultaneously
across multiple samples. Here an expanded set of 16 isobaric reagents based on an isobutyl-…

Cytochrome P450s are oxidative metabolic enzymes that play critical roles in the biotransformation
of endogenous compounds and xenobiotics. The expression and activity of P450 …

Only a small fraction of vitamin B 12 -requiring organisms are able to synthesize B 12 de
novo, making it a common commodity in microbial communities. Initially recognized as an …

Cross‐linking mass spectrometry (XL‐MS) is an attractive method for the proteome‐wide
characterization of protein structures and interactions. Currently, the depth of in vivo XL‐MS …

The development of renewable biofuels is a global priority, but success will require novel
technologies that greatly improve our understanding of microbial systems biology. An …

A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the
appropriate placement of substituents necessary to promote dual fluorescence (DF). As …

The first ratiometric fluorescent reporter was designed for the detection of cardiac troponin I (cTnI),
a key protein elicited during cardiac muscle cell death. In designing this abiotic …

The synthesis and photophysical characterization of a new white-light fluorophore is
described. The optimization of excitation wavelengths allows the naphthalimide (NI) dyes to …

Fluorescent probes 1 and 2 were conveniently synthesized from 4-sulfo-1, 8-naphthalic
anhydride, potassium salt, and 4′-aminobenzo-15-crown-5 and also from 4′-aminobenzo-18-…

The vitamin D receptor (VDR) is a nuclear hormone receptor that regulates cell proliferation,
cell differentiation, and calcium homeostasis. The receptor is activated by vitamin D …