[HTML][HTML] Overweight, obesity, and risk of age-related macular degeneration
QY Zhang, LJ Tie, SS Wu, PL Lv… - … & visual science, 2016 - iovs.arvojournals.org
Purpose: The aim of this study was to quantify the relationship between categories of body
mass index (BMI) and age-related macular degeneration (AMD) risk in different stages. …
mass index (BMI) and age-related macular degeneration (AMD) risk in different stages. …
[HTML][HTML] Phytochemicals: Current strategy to sensitize cancer cells to cisplatin
CY Sun, QY Zhang, GJ Zheng, B Feng - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Cisplatin-based chemotherapeutic regimens are the most frequently used adjuvant treatments
for many types of cancer. However, the development of chemoresistance to cisplatin …
for many types of cancer. However, the development of chemoresistance to cisplatin …
Bioengineered NRF2-siRNA is effective to interfere with NRF2 pathways and improve chemosensitivity of human cancer cells
The nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a transcription factor in the regulation
of many oxidative enzymes and efflux transporters critical for oxidative stress and cellular …
of many oxidative enzymes and efflux transporters critical for oxidative stress and cellular …
Deep convolutional neural network-aided detection of portal hypertension in patients with cirrhosis
…, H Ding, H Luo, C Zuo, C Liu, J Wang, C Zhang… - Clinical …, 2020 - Elsevier
Background & Aims Noninvasive and accurate methods are needed to identify patients with
clinically significant portal hypertension (CSPH). We investigated the ability of deep …
clinically significant portal hypertension (CSPH). We investigated the ability of deep …
[HTML][HTML] Structural basis of Sphingosine-1-phosphate transport via human SPNS2
Y Duan, NCP Leong, J Zhao, Y Zhang, DT Nguyen… - Cell Research, 2024 - nature.com
Dear Editor, Sphingosine 1-phosphate (S1P) plays crucial roles in various physiological
processes, including immune response, vascular development, and neural system homeostasis …
processes, including immune response, vascular development, and neural system homeostasis …
A reliable LC-MS/MS method for the quantification of natural amino acids in mouse plasma: method validation and application to a study on amino acid dynamics …
A simple and fast LC-MS/MS method was developed and validated for simultaneous
quantification of 20 proteinogenic l-amino acids (AAs) in a small volume (5 μL) of mouse plasma. …
quantification of 20 proteinogenic l-amino acids (AAs) in a small volume (5 μL) of mouse plasma. …
Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models
Our recent studies have revealed that microRNA-1291 (miR-1291) is downregulated in
pancreatic cancer (PC) specimens and restoration of miR-1291 inhibits tumorigenesis of PC cells…
pancreatic cancer (PC) specimens and restoration of miR-1291 inhibits tumorigenesis of PC cells…
[HTML][HTML] Complex polycyclic aromatic compound mixtures in PM2. 5 in a Chinese megacity: Spatio-temporal variations, toxicity, and source apportionment
Y Zeng, HM Ma, QY Zhang, L Tao, T Wang… - Environment …, 2023 - Elsevier
Polycyclic aromatic compounds (PACs) are important toxic organic components in fine
particulate matter (PM 2.5 ), whereas the links between PM 2.5 toxicity and associated PACs in …
particulate matter (PM 2.5 ), whereas the links between PM 2.5 toxicity and associated PACs in …
Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo
Recently we have established a novel approach to produce bioengineered noncoding RNA
agents (BERAs) in living cells that carry target RNAi molecules (eg, siRNA and miRNA) and …
agents (BERAs) in living cells that carry target RNAi molecules (eg, siRNA and miRNA) and …
[HTML][HTML] MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7
…, N Xu, J Li, LP Shen, YZ Zhang, S Koda, BB Zhang… - Parasites & …, 2021 - Springer
Background Various stimuli, including Clonorchis sinensis infection, can cause liver fibrosis.
Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs) with massive …
Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs) with massive …