Busulfan is an alkylating agent that is widely used in preparative regimens for bone marrow
transplantation (BMT). We developed a high-performance liquid chromatographic (HPLC) …

The relative alkylating activities of two of the cytotoxic metabolites of cyclophosphamide,
phosphoramide mustard and nornitrogen mustard, have been studied at pH 4.6 and 7.4. The …

MATERIALS AND METHODS Patient Selection and Drug Administration Patients included
in this pharmacologic study were those treated with taxol during the conduct of a phase I trial …

The plasma pharmacokinetics and urinary excretion of thalidomide have been evaluated in
eight healthy male volunteers receiving a single oral dose of 200 mg. Concentrations of …

The conjugations of cyclophosphamide and of phosphoramide mustard with glutathione are
shown to be catalyzed by hepatic cytosolic glutathione-S-transferases. Cyclophosphamide …

Unambiguous and sensitive methods based on gas chromatography-chemical ionization
mass spectrometry have been developed to quantitate cyclophosphamide and two alkylating …

Five alkyl derivatives of luminol (5-amino-2, 3-dihydrophthalazine-1, 4-dione) and two alkyl
derivatives of isolumi-nol (6-amino-2, 3-dihydrophthalazine-1, 4-dione) were prepared and …

A comparison of the aqueous decomposition products of several haloethylnitrosoureas has
led to a suggested mode of decomposition and antitumor effect for these compounds. 1,3-Bis-…

A simple and highly sensitive gas chromatographic method has been developed for the
determination of busulfan in human plasma. After extraction of plasma specimens (clinical or …

Hexamethylene bisacetamide (HMBA, NSC 95580) has been demonstrated to be the most
effective of the known and studied polar-planar compounds at inducing differentiation in a …