… occurred after residue 264 but not more distally (RF Burk, unpublished observation). This
lack of reactivity of the C-terminal domain suggests that it is shielded in the native protein. …

… Such vesicles were not detected in the testis [Olson, GEVP Winfrey, KE Hill, and RF Burk,
unpublished] but they were present in kidney PCT cells [46]. Because only one isoform of …

… (RF Burk, unpublished calculations). Based on these estimates, it is likely that the regulated
(specific) selenium pool in a selenium-replete person weighing 70 kg contains 10–15 mg …

Glutathione peroxidase activity in the liver supernatant from rats fed a Se-deficient diet for 2
weeks was 8% of control when measured with H 2 O 2 but 42% of control when assayed with …

Increasing attention has focused on the role of free radicals derived from oxygen in the
pathophysiology of a wide variety of disorders. One of the well-recognized targets of free radical-…

Selenoprotein P (Se-P) contains most of the selenium in plasma. Its function is not known.
Mice with the Se-P gene deleted (Sepp −/− ) were generated. Two phenotypes were observed…

METHODS A Medline search of the English language literature was performed. Articles
published between 1966 and December, 1989 were searched using the MESH terms “…

Background Selenium is an element necessary for normal cellular function, but it can have
toxic effects at high doses. We investigated an outbreak of acute selenium poisoning. …

Nearly all the selenium in animal tissues is associated with protein. Several protein-bound
forms have been identified, but only one, selenocysteine encoded by a UGA in mRNA, has …

Glutathione peroxidase has been recognized as a Se containing enzyme and its activity can
be reduced in many organs and tissues of animals by feeding a Se deficient diet. …