In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …

UDP-glucuronosyltransferases (UGT) catalyze the conjugation of lipophilic exobiotic and
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or urine…

Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase
1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products …

Kinetic and inhibitor studies using cDNA-expressed enzymes and human liver microsomes
have characterized the specificity of a range of cytochrome P450 (CYP) 1A substrate and …

Background and aims: The liver represents one of the major sites of human glucuronidation.
Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to …

Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts
the existence of at least nine individual proteins. The different proteins are generated by …

UDP-glucuronosyltransferases (UGTs) convert dietary constituents, drugs, and environmental
mutagens to inactive hydrophilic glucuronides. Recent studies have shown that the …

Triclosan (TCS) is a broad-spectrum antimicrobial agent that has been added to personal
care products, including hand soaps and cosmetics, and impregnated in numerous different …

The metabolism of ingested foods and orally administered drugs occurs in the hepato-gastrointestinal
tract. This process is facilitated by several supergene families that catalyze …

Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a synthetic, broad-spectrum
antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, …