Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E

R Kahl, H Kappus - Zeitschrift für Lebensmittel-Untersuchung und …, 1993 - Springer
The toxicology of the food preservatives butylhydroxyanisole (BHA) and butylhydroxytoluene
(BHT) as well as the naturally occurring vitamin E (α-tocopherol) is described. In high …

Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH)

…, W Dekant, H Foth, T Gebel, JG Hengstler, R Kahl… - Archives of …, 2008 - Springer
During the last two decades, substantial efforts have been made towards the development
and international acceptance of alternative methods to safety studies using laboratory animals…

Synthetic antioxidants: biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

R Kahl - Toxicology, 1984 - Elsevier
Biological actions of 4 commonly used synthetic antioxidants — butylated hydroxyanisole,
butylated hydroxytoluene, ethoxquin and propul gallate — on the molecular, cellular and …

[HTML][HTML] Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis

…, A Kampkötter, QH Tran-Thi, P Proksch, R Kahl - The Journal of …, 2005 - Elsevier
Dietary flavonoids possess a wide spectrum of biochemical and pharmacological actions
and are assumed to protect human health. These actions, however, can be antagonistic, and …

Dose-and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells

R Lüpertz, W Wätjen, R Kahl, Y Chovolou - Toxicology, 2010 - Elsevier
The cytostatic drug doxorubicin is a well-known chemotherapeutic agent which is used in
treatment of a wide variety of cancers. A key factor in the response of cancer cells to …

Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis …

…, C Timpel, Y Chovolou, W Wätjen, R Kahl - Archives of …, 2007 - Springer
Flavonoids present in many herbal edibles possess a remarkable spectrum of biochemical
and pharmacological actions and they are assumed to exert beneficial effects to human …

Transverse Asymmetry from the Quasielastic Process and the Neutron Magnetic Form Factor

…, JS Jensen, X Jiang, CE Jones, M Jones, R Kahl… - Physical Review Letters, 2000 - APS
We have measured the transverse asymmetry AT′ in 3 He→(e→, e′) quasielastic
scattering in Hall A at Jefferson Laboratory with high precision for Q 2 values from 0.1 to 0.6 (GeV/c) …

Hydrogen peroxide in expired breath condensate of patients with acute respiratory failure and with ARDS

D Kietzmann, R Kahl, M Müller, H Burchardi… - Intensive care …, 1993 - Springer
Objective Measurement of hydrogen peroxide concentrations in breath condensate of
mechanically ventilated patients with ARDS and with risk factors for developing ARDS. Design …

Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans

…, RF Zurawski, C Timpel, Y Chovolou, W Wätjen, R Kahl - Toxicology, 2007 - Elsevier
Oxidative stress as a result of excessive generation of reactive oxygen species (ROS) or
diminished antioxidative defence is regarded as a main factor in the pathophysiology of various …

Alterations of antioxidant enzyme expression in response to hydrogen peroxide

E Röhrdanz, R Kahl - Free Radical Biology and Medicine, 1998 - Elsevier
The effect of hydrogen peroxide (H 2 O 2 ) on the expression of different antioxidant enzymes
was investigated in primary rat hepatocytes and the rat hepatoma H4IIE cell line. Catalase …