Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate
JN Weinstein, RL Magin, RL Cysyk, DS Zaharko - Cancer research, 1980 - AACR
Liposomes can be designed to break down and release their contents preferentially in an
anatomical region subjected to local hyperthermia. Such “temperature-sensitive” liposomes, …
anatomical region subjected to local hyperthermia. Such “temperature-sensitive” liposomes, …
Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications
RL Cysyk, RJ Parker, JJ Barchi, PS Steeg… - Chemical research in …, 2006 - ACS Publications
17-Dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and 17-allylamino-17-demethoxygeldanamycin
(17-AAG) are two derivatives of geldanamycin (GA) that are …
(17-AAG) are two derivatives of geldanamycin (GA) that are …
Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors
RW Klecker, RL Cysyk, JM Collins - Bioorganic & medicinal chemistry, 2006 - Elsevier
To aid in the clinical evaluation of zebularine, a potential oral antitumor agent, we initiated
studies on the metabolism of zebularine in liver cytosol from humans and other mammals. …
studies on the metabolism of zebularine in liver cytosol from humans and other mammals. …
Cyclopentenyluridine and cyclopentenylcytidine analogs as inhibitors of uridine-cytidine kinase
MI Lim, JD Moyer, RL Cysyk… - Journal of medicinal …, 1984 - ACS Publications
“Uridine kinase from L1210 cells was prepared and assayed as described by Ahmed and
Baker. 12 In brief, the phosphorylation of [14C]-uridine (40 µ) at 37 “C was measured by the …
Baker. 12 In brief, the phosphorylation of [14C]-uridine (40 µ) at 37 “C was measured by the …
Determination of serum and plasma uridine levels in mice, rats, and humans by high-pressure liquid chromatography
JM Karle, LW Anderson, DD Dietrick, RL Cysyk - Analytical biochemistry, 1980 - Elsevier
Serum and plasma uridine levels in mice, rats, and humans were conveniently measured by
reverse-phase high-pressure liquid chromatography. Human serum levels were in the …
reverse-phase high-pressure liquid chromatography. Human serum levels were in the …
Isolation and characterization by electrospray-ionization mass spectrometry and high-performance anion-exchange chromatography of oligosaccharides derived from …
…, A Tuinman, DC Baker, C Chisena, RL Cysyk - Carbohydrate …, 1997 - Elsevier
Hyaluronic acid was degraded with hyaluronate lyase (EC 4.2.2.1, from Streptomyces
hyalurolyticus), and the resulting oligosaccharides up to dp 16 were characterized by electrospray-…
hyalurolyticus), and the resulting oligosaccharides up to dp 16 were characterized by electrospray-…
Contribution of de‐novo and salvage synthesis to the uracil nucleotide pool in mouse tissues and tumors in vivo
…, R Hyman, JM Strong, RL Cysyk - European journal of …, 1992 - Wiley Online Library
The relative contribution of de‐novo and salvage synthesis to tissue pyrimidine nucleotide
pools is an important parameter in the rational design of anti‐pyrimidine therapies, but has not …
pools is an important parameter in the rational design of anti‐pyrimidine therapies, but has not …
Effect of plasma concentrations of uridine on pyrimidine biosynthesis in cultured L1210 cells.
JM Karle, LW Anderson, RL Cysyk - Journal of Biological Chemistry, 1984 - ASBMB
The concentration of uridine in the media of cultured L1210 cells was maintained within the
concentration range found in plasma (1 to 10 microM) to determine if such concentrations …
concentration range found in plasma (1 to 10 microM) to determine if such concentrations …
m-AMSA and PALA: Two new agents in cancer chemotherapy
M Rozencweig, DD Von Hoff, RL Cysyk… - Cancer Chemotherapy …, 1979 - Springer
… Cysyk, unpublished results). After oral administration of 14C-m-AMSA to rats (100 mg/kg),
60%-90% of the radioactivity can be recovered in the bile (Rozencweig and Cysyk, … by Cysyk …
60%-90% of the radioactivity can be recovered in the bile (Rozencweig and Cysyk, … by Cysyk …
Synthesis and release of hyaluronic acid by Swiss 3T3 fibroblasts
JR Kitchen, RL Cysyk - Biochemical Journal, 1995 - portlandpress.com
Hyaluronic acid (HA) and its synthesis were studied in intact Swiss 3T3 mouse fibroblasts
and isolated membranes. HA chains in culture medium, attached to cells and in isolated …
and isolated membranes. HA chains in culture medium, attached to cells and in isolated …