Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites
…, N Krishnamachary, M Shou, A Ogai, RA Parise… - Biochemistry, 1998 - ACS Publications
Some cytochrome P450 catalyzed reactions show atypical kinetics, and these kinetic
processes can be grouped into five categories: activation, autoactivation, partial inhibition, …
processes can be grouped into five categories: activation, autoactivation, partial inhibition, …
Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies
SS Ramalingam, RA Parise, RK Ramananthan… - Clinical cancer …, 2007 - AACR
Purpose: The primary objective of this study was to determine the recommended phase II
doses of the novel histone deacetylase inhibitor vorinostat when administered in combination …
doses of the novel histone deacetylase inhibitor vorinostat when administered in combination …
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
…, A Bommareddy, D Desai, S Amin, RA Parise… - Cancer research, 2009 - AACR
The present study shows that oral gavage of 6 μmol d,l-sulforaphane (SFN), a synthetic
analogue of cruciferous vegetable-derived L isomer, thrice per week beginning at 6 weeks of age…
analogue of cruciferous vegetable-derived L isomer, thrice per week beginning at 6 weeks of age…
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z, E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice
J Guo, RA Parise, E Joseph, MJ Egorin, JS Lazo… - Cancer chemotherapy …, 2009 - Springer
Objectives c-Myc is commonly activated in many human tumors and is functionally important
in cellular proliferation, differentiation, apoptosis and cell cycle progression. The activity of c-…
in cellular proliferation, differentiation, apoptosis and cell cycle progression. The activity of c-…
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization
DM Clausen, J Guo, RA Parise, JH Beumer… - … of Pharmacology and …, 2010 - ASPET
The c-Myc oncoprotein is overexpressed in many tumors and is essential for maintaining the
proliferation of transformed cells. To function as a transcription factor, c-Myc must dimerize …
proliferation of transformed cells. To function as a transcription factor, c-Myc must dimerize …
[PDF][PDF] Oligoadenylate-synthetase-family protein OASL inhibits activity of the DNA sensor cGAS during DNA virus infection to limit interferon production
Interferon-inducible human oligoadenylate synthetase-like (OASL) and its mouse ortholog,
Oasl2, enhance RNA-sensor RIG-I-mediated type I interferon (IFN) induction and inhibit RNA …
Oasl2, enhance RNA-sensor RIG-I-mediated type I interferon (IFN) induction and inhibit RNA …
CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer
RA Parise, MJ Egorin, B Kanterewicz… - … journal of cancer, 2006 - Wiley Online Library
1α,25‐Dihydroxyvitamin D 3 (1,25D 3 ) displays potent antiproliferative activity in a variety of
tumor model systems and is currently under investigation in clinical trials in cancer. Studies …
tumor model systems and is currently under investigation in clinical trials in cancer. Studies …
Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyltransferase inhibitor, zebularine
JL Holleran, RA Parise, E Joseph, JL Eiseman… - Clinical cancer …, 2005 - AACR
Purpose: Zebularine is a DNA methyltransferase inhibitor proposed for clinical evaluation.
Experimental Design: We developed a liquid chromatography/mass spectrometry assay and …
Experimental Design: We developed a liquid chromatography/mass spectrometry assay and …
Sensitive liquid chromatography–mass spectrometry assay for quantitation of docetaxel and paclitaxel in human plasma
RA Parise, RK Ramanathan, WC Zamboni… - … of Chromatography B, 2003 - Elsevier
We have developed a high-performance liquid chromatography–electrospray ionization mass
spectrometry (LC–MS) method for quantifying docetaxel and paclitaxel in human plasma. …
spectrometry (LC–MS) method for quantifying docetaxel and paclitaxel in human plasma. …
Plasma, tumor, and tissue disposition of STEALTH liposomal CKD-602 (S-CKD602) and nonliposomal CKD-602 in mice bearing A375 human melanoma xenografts
…, E Joseph, DR Walsh, BA Zamboni, RA Parise… - Clinical cancer …, 2007 - AACR
Purpose: S-CKD602 is a STEALTH liposomal formulation of CKD-602, a camptothecin analogue.
The cytotoxicity of camptothecin analogues is related to the duration of exposure in the …
The cytotoxicity of camptothecin analogues is related to the duration of exposure in the …