Human UDP-glucuronosyltransferases: metabolism, expression, and disease
RH Tukey, CP Strassburg - Annual review of pharmacology and …, 2000 - annualreviews.org
In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
[HTML][HTML] Expression of the UDP-glucuronosyltransferase 1A locus in human colon: identification and characterization of the novel extrahepatic UGT1A8
CP Strassburg, MP Manns, RH Tukey - Journal of Biological Chemistry, 1998 - ASBMB
UDP-glucuronosyltransferases (UGT) catalyze the conjugation of lipophilic exobiotic and
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or urine…
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or urine…
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
…, BS Bottroff, GY Cabrera, RH Tukey… - Proceedings of the …, 2003 - National Acad Sciences
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase
1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products …
1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products …
[PDF][PDF] Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.
…, ME Veronese, ME McManus, RH Tukey… - … of Pharmacology and …, 1993 - Citeseer
Kinetic and inhibitor studies using cDNA-expressed enzymes and human liver microsomes
have characterized the specificity of a range of cytochrome P450 (CYP) 1A substrate and …
have characterized the specificity of a range of cytochrome P450 (CYP) 1A substrate and …
Developmental aspects of human hepatic drug glucuronidation in young children and adults
…, A Strassburg, S Kneip, A Barut, RH Tukey… - Gut, 2002 - gut.bmj.com
Background and aims: The liver represents one of the major sites of human glucuronidation.
Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to …
Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to …
Differential Expression of the UGT1A Locus in Human Liver, Biliary, and Gastric Tissue: Identification ofUGT1A7 and UGT1A10 Transcripts in Extrahepatic Tissue
CP Strassburg, K Oldhafer, MP Manns, RH Tukey - Molecular pharmacology, 1997 - ASPET
Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts
the existence of at least nine individual proteins. The different proteins are generated by …
the existence of at least nine individual proteins. The different proteins are generated by …
[HTML][HTML] Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
…, P Obermayer-Straub, A Barut, RH Tukey… - Journal of Biological …, 2000 - ASBMB
UDP-glucuronosyltransferases (UGTs) convert dietary constituents, drugs, and environmental
mutagens to inactive hydrophilic glucuronides. Recent studies have shown that the …
mutagens to inactive hydrophilic glucuronides. Recent studies have shown that the …
Triclosan: a widespread environmental toxicant with many biological effects
MF Yueh, RH Tukey - Annual review of pharmacology and …, 2016 - annualreviews.org
Triclosan (TCS) is a broad-spectrum antimicrobial agent that has been added to personal
care products, including hand soaps and cosmetics, and impregnated in numerous different …
care products, including hand soaps and cosmetics, and impregnated in numerous different …
The commonly used antimicrobial additive triclosan is a liver tumor promoter
…, BD Hammock, M Karin, RH Tukey - Proceedings of the …, 2014 - National Acad Sciences
Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a synthetic, broad-spectrum
antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, …
antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, …
Metabolism of 2-Acetylaminofluorene and Benzo(a)pyrene and Activation of Food-derived Heterocyclic Amine Mutagens by Human Cytochromes P-450
…, ME Veronese, A Huggett, LC Quattrochi, RH Tukey - Cancer Research, 1990 - AACR
… and Tukey. RH Cloning and isolation of human cytochrome P-450 cDNAs homologous to
dioxin- … Tukey, RH, and Neben, DW Regulation of mouse cytochrome P,-450 …
dioxin- … Tukey, RH, and Neben, DW Regulation of mouse cytochrome P,-450 …