Evaluation of methods for detecting alloantibodies underlying warm autoantibodies

RM Leger, G Garratty - Transfusion, 1999 - Wiley Online Library
BACKGROUND: In pretransfusion testing of patients whose sera contain autoantibodies
reacting optimally at 37C, it must be determined whether alloantibodies are also present. Two …

Serologic findings in autoimmune hemolytic anemia associated with immunoglobulin M warm autoantibodies

PA Arndt, RM Leger, G Garratty - Transfusion, 2009 - Wiley Online Library
BACKGROUND: Autoimmune hemolytic anemia (AIHA) associated with immunoglobulin M (IgM)
warm autoantibodies is unusual but often severe, with more fatalities than other types …

Clinical eftects and pharmacokinetics of racemic methadone and its optical isomers

…, HA Wendel, JO Livermore, RM Leger… - Clinical …, 1977 - Wiley Online Library
The respiratory and pupillary effects of oral l‐, d‐, and d,l‐methadone were studied in
healthy male volunteers 21 to 35 yr of age. The mean half‐life of drug in blood was 22 hr for …

Serology of antibodies to second‐and third‐generation cephalosporins associated with immune hemolytic anemia and/or positive direct antiglobulin tests

PA Arndt, RM Leger, G Garratty - Transfusion, 1999 - Wiley Online Library
BACKGROUND: First‐generation cephalosporins rarely caused immune hemolytic anemia (IHA).
Second‐ and third‐generation cephalosporins, especially cefotetan and ceftriaxone, …

Serologic characteristics of ceftriaxone antibodies in 25 patients with drug‐induced immune hemolytic anemia (CME)

PA Arndt, RM Leger, G Garratty - Transfusion, 2012 - Wiley Online Library
BACKGROUND: Ceftriaxone, a third‐generation cephalosporin, is commonly used to
prevent and treat infections. Since 1987, it has been the second most common cause of drug‐…

The chemokines IP-10/CXCL10 and IL-8/CXCL8 are potential novel biomarkers of warm autoimmune hemolytic anemia

DR Branch, RM Leger, D Sakac, Q Yi, T Duong… - Blood …, 2023 - ashpublications.org
Leger, … LegerLeger, Darinka Sakac, Qilong Yi, Trang Duong, Rae SM Yeung, Beth
Binnington, Evgenia M. Bloch; The chemokines IP-10/CXCL10 and IL-8/CXCL8 are potential …

In vitro studies of the impact of transfusion on the detection of alloantibodies after autoadsorption

EP Laine, RM Leger, PA Arndt, L Calhoun… - …, 2000 - Wiley Online Library
BACKGROUND: In a patient with warm autoantibodies who has recently received a
transfusion, it is not recommended to perform adsorptions using autologous RBCs to detect …

Serological studies of piperacillin antibodies

RM Leger, PA Arndt, G Garratty - Transfusion, 2008 - Wiley Online Library
BACKGROUND: Penicillin‐induced immune hemolytic anemia (IHA) is associated with
immunoglobulin G antipenicillin detected by testing penicillin‐coated red blood cells (RBCs). …

[HTML][HTML] Piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis

M Bandara, DB Seder, G Garratty, RM Leger… - Case Reports in …, 2010 - hindawi.com
We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with
cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with …

Drug‐induced immune hemolytic anemia associated with anti‐vancomycin complicated by a paraben antibody

TJ Gniadek, PA Arndt, RM Leger, D Zydowicz… - …, 2018 - Wiley Online Library
BACKGROUND Drug‐induced immune hemolytic anemia (DIIHA) is rare, but potentially life‐threatening.
A high index of clinical suspicion is required for diagnosis, since the number of …