Historically, the discovery of the helical structure of DNA by Watson and Crick1 provided the
impetus to attempt the challenging synthesis of oligonucleotides of defined sequences. …

Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates
pathological remodeling processes that involve inflammation and fibrosis in cardiovascular …

Although the application of nucleosidic and non nucleosidic phosphoramidite derivatives to
the preparation and functionalization of oligonucleotides has recently been reviewed, 192 …

Oligodeoxyribonucleoside phosphorothioates are isoelectronic analogues of natural
phosphodiesters in which one of the oxygen atoms that does not participate in the internucleotidic …

The rapid growth of biotechnology has triggered an increasing demand for modified
oligonucleotides dedicated mostly to diagnostic and therapeutic applications. The plethoric number …

Inflammation resolution is important for scar formation following myocardial infarction (MI)
and requires the coordinated actions of macrophages and fibroblasts. In this study, we …

Several polysulfides were tested as potential sulfur-transfer reagents during the automated
synthesis of oligodeoxyribonucleoside phosphorothioates via the “deoxyribonucleoside …

Aims Although macrophage phenotypes have been well studied in the myocardial infarction
(MI) setting, this study investigated temporal neutrophil polarization and activation …

Since the discovery of tadpole collagenase in 1962, the matrix metalloproteinase (MMP)
family has emerged as a significant proteinase group with recognized effects on the …

In response to myocardial infarction (MI), the wound healing response of the left ventricle (LV)
comprises overlapping inflammatory, proliferative, and maturation phases, and the cardiac …