The UDP-glucuronosyltransferase (UGT) 1A enzymes are involved in the phase II metabolism
of many important endogenous and exogenous compounds. The nine UGT1A isoforms …

Some patients with cancer never develop metastasis, and their host response might provide
cues for innovative treatment strategies. We previously reported an association between …

… Recently completed studies have also shown that UGT2A1 is unable to metabolize substrates
using these alternate sugars (RT Bushey and P. Lazarus, unpublished data), suggesting …

Abstract Characterization of the humoral immune response in selected patients with cancer
who uniformly do well may lead to the development of novel therapeutic strategies. We have …

… RT-PCR assays were performed using pooled RNA from at least three normal samples for
each organ/tissue. Two micrograms of RNA was used for RT using a Superscript II RT … by RT-…

The elimination of cancer cells critically depends on the immune system. However, cancers
have evolved a variety of defense mechanisms to evade immune monitoring, leading to …

… in multiple respiratory, digestive, and aerodigestive tract tissues (Bushey et al., 2011). In the
present study, RT-PCR amplification of UGT2A1 from pooled lung RNA yielded two distinct …

Introduction In vivo, cancer cells respond to signals from the tumor microenvironment resulting
in changes in expression of proteins that promote tumor progression and suppress anti-…

Exosomes are a class of extracellular vesicles (EVs) that are mediators of normal intercellular
communication, but exosomes are also used by tumor cells to promote oncogenesis and …

Abstract Development of novel therapeutic antibodies that not only kill tumor cells but
modulate the adaptive immune response has the potential to produce long term anticancer …