Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.
…, N Chacos, J Werringloer, RA Prough… - Proceedings of the …, 1981 - National Acad Sciences
Arachidonic acid is oxidatively metabolized by rat liver microsomes at a rate of approximately
5 nmol per min per mg of protein at 25 degrees C. This reaction is dependent on the …
5 nmol per min per mg of protein at 25 degrees C. This reaction is dependent on the …
Nuclear receptors and nonalcoholic fatty liver disease
…, H Shi, BA Aqel, CJ McClain, RA Prough - … et Biophysica Acta (BBA …, 2016 - Elsevier
Nuclear receptors are transcription factors which sense changing environmental or hormonal
signals and effect transcriptional changes to regulate core life functions including growth, …
signals and effect transcriptional changes to regulate core life functions including growth, …
The biological actions of dehydroepiandrosterone involves multiple receptors
SJ Webb, TE Geoghegan, RA Prough… - Drug metabolism …, 2006 - Taylor & Francis
… , respectively (RW Estabrook and RA Prough, data not shown). … Lei and RA Prough, data
not shown). The metabolism in vitro … null mice (SJ Webb and RA Prough, unpublished results). …
not shown). The metabolism in vitro … null mice (SJ Webb and RA Prough, unpublished results). …
Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency
MW Linder, RA Prough, R Valdes Jr - Clinical Chemistry, 1997 - academic.oup.com
Pharmacogenetics is the study of the linkage between an individual’s genotype and that
individual’s ability to metabolize a foreign compound. Differences in metabolism of therapeutics …
individual’s ability to metabolize a foreign compound. Differences in metabolism of therapeutics …
[HTML][HTML] Novel mechanisms for DHEA action
… In Pxr-null mice, we did not observe P4503A11 induction upon DHEA feeding (SJ Webb and
RA Prough, unpublished observations). Other experiments demonstrated that DHEA, Adiol, …
RA Prough, unpublished observations). Other experiments demonstrated that DHEA, Adiol, …
Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.
…, LJ Marnett, N Chacos, RA Prough… - Proceedings of the …, 1982 - National Acad Sciences
Arachidonic acid is oxidized by a NADPH-dependent oxygenase of rat liver microsomes to
a number of oxygen-containing products, which can be resolved by HPLC. Several of these …
a number of oxygen-containing products, which can be resolved by HPLC. Several of these …
[39] Direct fluorometric methods for measuring mexed-function oxidase activity
RA Prough, MD Burke, RT Mayer - Methods in enzymology, 1978 - Elsevier
Publisher Summary This chapter focuses on the direct fluorometric methods for measuring
mixed-function oxidase activity. Ullrich and Weber developed a direct fluorometric method to …
mixed-function oxidase activity. Ullrich and Weber developed a direct fluorometric method to …
Identification of environmental chemicals associated with the development of toxicant-associated fatty liver disease in rodents
…, JJ Guardiola, HB Clair, RA Prough… - Toxicologic …, 2015 - journals.sagepub.com
Background: Toxicant-associated fatty liver disease (TAFLD) is a recently identified form of
nonalcoholic fatty liver disease (NAFLD) associated with exposure to industrial chemicals …
nonalcoholic fatty liver disease (NAFLD) associated with exposure to industrial chemicals …
Mechanisms of environmental contributions to fatty liver disease
…, RD Schnegelberger, KC Falkner, RA Prough… - Current environmental …, 2019 - Springer
Purpose Fatty liver disease (FLD) affects over 25% of the global population and may lead to
liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and …
liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and …
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke
DJ Conklin, P Haberzettl, RA Prough… - American Journal of …, 2009 - journals.physiology.org
Exposure to tobacco smoke impairs endothelium-dependent arterial dilation. Reactive
constituents of cigarette smoke are metabolized and detoxified by glutathione-S-transferases (…
constituents of cigarette smoke are metabolized and detoxified by glutathione-S-transferases (…