Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health …

…, A González‐Sarrías, R GarcíaVillalba… - Molecular nutrition & …, 2017 - Wiley Online Library
Urolithins are dibenzo[b,d]pyran‐6‐one derivatives that are produced by the human gut
microbiota from ellagitannins and ellagic acid (EA). These metabolites are much better absorbed …

Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and …

FA Tomás-Barberán, R García-Villalba… - Journal of agricultural …, 2014 - ACS Publications
Three phenotypes for urolithin production after ellagitannin and ellagic acid intake are
consistently observed in different human intervention trials. Subjects can be stratified into three …

Alternative method for gas chromatography‐mass spectrometry analysis of short‐chain fatty acids in faecal samples

R GarcíaVillalba, JA Giménez‐Bastida… - Journal of separation …, 2012 - Wiley Online Library
Short‐chain fatty acids are the major end products of bacterial metabolism in the large bowel.
They derive mostly from the bacterial breakdown of carbohydrates and are known to have …

Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species

MV Selma, D Beltrán, R García-Villalba, JC Espín… - Food & function, 2014 - pubs.rsc.org
Ellagitannin and ellagic acid metabolism to urolithins in the gut shows a large human
interindividual variability and this has been associated with differences in the colon microbiota. In …

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

MA Nuñez‐Sánchez, R GarcíaVillalba… - Molecular nutrition & …, 2014 - Wiley Online Library
Scope Urolithins are bioactive metabolites produced by the gut microbiota from ellagitannins
(ETs) and ellagic acid (EA). We investigated whether urolithins could be detected in colon …

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese …

A González‐Sarrías, R GarcíaVillalba… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope The pomegranate lipid‐lowering properties remain controversial, probably due to the
interindividual variability in polyphenol (ellagitannins) metabolism. Objective We aimed at …

In vitro transformation of chlorogenic acid by human gut microbiota

F Tomas‐Barberan, R GarcíaVillalba… - Molecular nutrition & …, 2014 - Wiley Online Library
Scope Chlorogenic acid (3‐ O ‐caffeoyl‐quinic acid, C ‐ QA ), the caffeic ester of quinic acid,
is one of the most abundant phenolic acids in Western diet. The majority of C ‐ QA escapes …

Time course production of urolithins from ellagic acid by human gut microbiota

R García-Villalba, D Beltrán, JC Espín… - Journal of agricultural …, 2013 - ACS Publications
Ellagic acid (EA) is converted to urolithins by gut microbiota. Urolithins have beneficial
biological effects in humans, but differences in urolithin production capacity among individuals …

[HTML][HTML] Isolation of human intestinal bacteria capable of producing the bioactive metabolite isourolithin a from ellagic acid

…, M Romo-Vaquero, R García-Villalba… - Frontiers in …, 2017 - frontiersin.org
Urolithins are intestinal microbial metabolites produced from ellagitannin- and ellagic acid-containing
foods such as walnuts, strawberries, and pomegranates. These metabolites, better …

[HTML][HTML] Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts

A González-Sarrías, R García-Villalba… - Journal of Functional …, 2015 - Elsevier
Ellagic acid (EA) is a polyphenol that must be released from the non-bioavailable ellagitannins
in pomegranates, walnuts or strawberries to be absorbed. To estimate whether EA …