Metabolism of bisphenol A in primary cultured hepatocytes from mice, rats, and humans

JJ Pritchett, RK Kuester, IG Sipes - Drug Metabolism and Disposition, 2002 - ASPET
Studies have shown that in the rat, bisphenol A (BPA) is metabolized and eliminated primarily
as a monoglucuronide, a metabolite without estrogenic activity. The purpose of this study …

Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats

RK Kuester, MP Waalkes, PL Goering… - Toxicological …, 2002 - academic.oup.com
A number of reports document that Fischer 344 (F344) rats are more susceptible to chemically
induced liver injury than Sprague-Dawley (SD) rats. Cadmium (CdCl 2 ), a hepatotoxicant …

Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse

JD Lambert, D Zhao, RO Meyers, RK Kuester… - Toxicon, 2002 - Elsevier
Larrea tridentata (Moc & Sess) Cov. (Zygophyllaceae) is an ethnobotanically important plant
found in the American Southwest and northern Mexico. Although numerous beneficial …

The effects of dose, route, and repeated dosing on the disposition and kinetics of tetrabromobisphenol A in male F-344 rats

RK Kuester, AM Sólyom, VP Rodriguez… - Toxicological …, 2007 - academic.oup.com
Studies were conducted to characterize the metabolic and dispositional fate of 14 C–tetrabromobisphenol
A (TBBPA)—a commonly used brominated flame retardant, in male Fischer-…

Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat

JM Sauer, MP Waalkes, SB Hooser, RK Kuester… - Toxicology, 1997 - Elsevier
Exposure of humans to toxic metals and metalloids is a major environmental problem. Many
metals, such as cadmium, can be hepatotoxic. However, the mechanisms by which metals …

Disposition and metabolism of isoeugenol in the male Fischer 344 rat

DA Badger, RL Smith, J Bao, RK Kuester… - Food and chemical …, 2002 - Elsevier
The primary objective of these studies was to determine the absorption, distribution,
metabolism and excretion of isoeugenol following oral and intravenous administration to male …

Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity

DA Badger, RK Kuester, JM Sauer, IG Sipes - Toxicology, 1997 - Elsevier
The Kupffer cell inhibitor, gadolinium chloride (GdCl 3 ), protects the liver from a number of
toxicants that require biotransformation to elicit toxicity (ie 1,2-dichlorobenzene and CCl 4 ), …

Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2, 3-dibromopropyl ether] in male Fischer-344 rats

GA Knudsen, LM Jacobs, RK Kuester, IG Sipes - Toxicology, 2007 - Elsevier
Tetrabromobisphenol A bis[2,3-dibromopropyl ether],2,2-bis[3,5-dibromo-4-(2,3-dibromopropoxy)phenyl]propane
is a brominated flame retardant with substantial US production. Due to …

Prediction of metabolic clearance of bisphenol A (4, 4′-dihydroxy-2, 2-diphenylpropane) using cryopreserved human hepatocytes

RK Kuester, IG Sipes - Drug Metabolism and Disposition, 2007 - ASPET
This study investigated the kinetics of glucuronidation of bisphenol A (BPA; 4,4′-dihydroxy-2,2-diphenylpropane)
in cryopreserved human hepatocytes (HCs). Incubation conditions …

Synergistic induction of tumor necrosis factor α by bacterial lipopolysaccharide and lipoteichoic acid in combination with polytetrafluoroethylene particles in a murine …

MS Chapekar, TG Zaremba, RK Kuester… - … Research: An Official …, 1996 - Wiley Online Library
The induction of tumor necrosis factor α (TNF‐α) by polytetrafluoroethylene (PTFE) particles
(5–50 μm) and by bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA) was …