[HTML][HTML] Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator

RL Haining, C Achat-Mendes - Neural regeneration research, 2017 - journals.lww.com
The loss of pigmented neurons from the human brain has long been the hallmark of Parkinson's
disease (PD). Neuromelanin (NM) in the pre-synaptic terminal of dopamine neurons is …

The human intestinal cytochrome P450 “pie”

MF Paine, HL Hart, SS Ludington, RL Haining… - Drug metabolism and …, 2006 - ASPET
Cytochromes P450 (P450s) 3A, 2C, and 1A2 constitute the major “pieces” of the human
liver P450 “pie” and account, on average, for 40, 25, and 18%, respectively, of total …

Genetic association between sensitivity to warfarin and expression of CYP2C9* 3

DJ Steward, RL Haining, KR Henne… - Pharmacogenetics …, 1997 - journals.lww.com
Cytochrome P4502C9 (CYP2C9) is largely responsible for terminating the anticoagulant
effect of racemic warfarin via hydroxylation of the pharmacologically more potent S-enantiomer …

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral …

RL Haining, AP Hunter, ME Veronese… - Archives of biochemistry …, 1996 - Elsevier
The purpose of the present studies was to define the role of the I359L allelic variant of CYP2C9
in the metabolism of the low therapeutic index anticoagulant warfarin, by performingin …

Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CYP2D6 …

A Yu, RL Haining - Drug Metabolism and Disposition, 2001 - ASPET
Dextromethorphan (DXM) is a widely used probe drug for human CYP2D6 activity both in
vitro and in vivo. In humans, DXM is metabolized to dextrorphan (DXO), as well as 3-…

Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen

H Dong, RL Haining, KE Thummel, AE Rettie… - Drug metabolism and …, 2000 - ASPET
Acetaminophen (APAP), a widely used analgesic and antipyretic agent, can cause acute
hepatic necrosis in both humans and experimental animals when consumed in large doses. It …

CYP2C-catalyzed delta (9)-tetrahydrocannabinol metabolism: Kinetics, pharmacogenetics and interaction with phenytoin

TM Bland, RL Haining, TS Tracy, PS Callery - Biochemical pharmacology, 2005 - Elsevier
delta(9)-Tetrahydrocannabinol (Δ 9 -THC), the primary psychoactive constituent of marijuana,
is subject to first pass hepatic metabolism primarily by hydroxylation to yield active and …

Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6. 1, 2D6. 2, 2D6. 10, and 2D6. 17 allelic isoforms

A Yu, BM Kneller, AE Rettie, RL Haining - Journal of Pharmacology and …, 2002 - ASPET
Polymorphism at the cytochrome P450 2D6 (CYP2D6) locus is one of the most widely known
causes of pharmacogenetic variability in humans. Our goal is to investigate the intrinsic …

A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin

AE Rettie, RL Haining, M Bajpai, RH Levy - Epilepsy research, 1999 - Elsevier
CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We
have shown previously that mutations in the CYP2C9 gene are associated with diminished …

Polymorphic variants (CYP2C9* 3 and CYP2C9* 5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles

TS Tracy, JM Hutzler, RL Haining, AE Rettie… - Drug Metabolism and …, 2002 - ASPET
CYP2C9 wild-type protein has been shown to exhibit atypical kinetic profiles of metabolism
that may affect in vitro-in vivo predictions made during the drug development process. …