For the last four decades, the treatment of cancer has relied on four treatment modalities,
namely surgery, radiotherapy, cytotoxic chemotherapy, and hormonotherapy. Most of these …

… Champbme MH, Bitche I, Lizard S, Lidereau R (1995b) llq13 amplification is involved in
local recurrence of human primary breast cancer. Genes Chromosom Cancer 12: 128-133. …

Conventional cancer treatments rely on radiotherapy and chemotherapy. Such treatments
supposedly mediate their effects via the direct elimination of tumor cells. Here we show that …

The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs),
which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–…

Background: A 70-gene signature was previously shown to have prognostic value in
patients with node-negative breast cancer. Our goal was to validate the signature in an …

Purpose: Recently, a 76-gene prognostic signature able to predict distant metastases in
lymph node–negative (N − ) breast cancer patients was reported. The aims of this study …

To investigate the clinical value of somatic TP53 mutations in breast cancer, we assembled
clinical and molecular data on 1,794 women with primary breast cancer with long-term follow-…

So far, no common environmental and/or phenotypic factor has been associated with
melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun …

We have studied the genomic organization of the c-myc locus (MYC) from 121 human primary
breast carcinomas. Two types of alterations were observed: (i) the c-myc protooncogene …

There is genetic predisposition associated with ⩾10% of all cancer of the prostate (CaP). By
means of a genomewide search on a selection of 47 French and German families, …