We describe a comprehensive retrospective analysis in which the abilities of several
methods by which human pharmacokinetic parameters are predicted from preclinical …

The measurement of the effect of new chemical entities on human cytochrome P450 marker
activities using in vitro experimentation represents an important experimental approach in …

Twenty-nine drugs of disparate structures and physicochemical properties were used in an
examination of the capability of human liver microsomal lability data (“in vitroT 1/2 ” approach…

The ability to use vitro inactivation kinetic parameters in scaling to in vivo drug-drug interactions
(DDIs) for mechanism-based inactivators of human cytochrome P450 (P450) enzymes …

The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …

Current regulatory guidances do not address specific study designs for in vitro and in vivo
drug-drug interaction studies. There is a common desire by regulatory authorities and by …

The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a
drug has been released can lead to a severe restriction in its use and even in its withdrawal. …

COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease
is a virally encoded protein that is essential across a broad spectrum of coronaviruses with …

Commercially available St. John's wort (Hypericum perforatum) extracts, preparations that
are used in the treatment of depression, were examined for the potential to inhibit human …

Organic compounds containing five-membered aromatic heterocyclic rings are widely
distributed in nature and often play an important role in various biochemical processes. …