CYP3A proteins comprise a significant portion of the hepatic cytochrome P450 (CYP) protein
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …

… The Pearson correlation coefficient (r) was calculated for normally distributed data, and the
Spearman rank correlation coefficient (rJ was calculated for data not normally distributed. For …

The elucidation of the individual contributions of the fourCYP3A genes to the overall CYP3A
activity has been hampered by similarities in their sequence and function. We investigated …

… Functional differences between CYP3A7 andCYP3A7*1C proximal promoter ER6 (evertedrepeat
separated by 6 base pairs) motifs in binding and activation by the nuclear receptors …

… Furthermore, Z‐4‐hydroxy‐tamoxifen formation significantly correlated with both CYP2C9
expression (r s =0.256, P<0.05) and CYP2D6 expression (r s =0.309, P<0.05). Genotypes of …

… The formation of N-desmethyl-tam was also significantly associated with CYP2B6 and
CYP2C9 expression (r s = 0.302, P < 0.05 and r s = 0.289, P < 0.05, respectively). No association …

Objectives The small intestinal wall serves as an important barrier for the entry of foreign
substances into the organism. Of particular importance are enzymes and transporters that can …

(CYP), show higher clearance in women than in men. Although this effect is believed to be
related to drug metabolism, the underlying cause has not been elucidated. We investigated …

High power excimer laser ablation projection tools have been used successfully in IBM
manufacturing for about four years. One hundred fifty W XeCL, 300 mJ per pulse and 500 mJ per …

The special requirements and possibilities of laser spatial intensity profiling in the UV
spectral range are discussed in this paper, along with a description of a high resolution beam …