RIP1 regulates necroptosis and inflammation and may play an important role in contributing
to a variety of human pathologies, including immune-mediated inflammatory diseases. Small…

During this century, several investigators reported that certain viruses, metais, drugs, and
other solutes could bypass systemic circulation and enter the brain and/or cerebrospinal fluid …

The recent discovery of the role of receptor interacting protein 1 (RIP1) kinase in tumor
necrosis factor (TNF)-mediated inflammation has led to its emergence as a highly promising …

The activation of the TRPM8 channel, a member of the large class of TRP ion channels, has
been reported to be involved in overactive bladder and painful bladder syndrome, although …

Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines,
and furo[2,3-d]pyrimidines, all of the type II class recognizing a DLG-out inactive …

RIP2 kinase is a central component of the innate immune system and enables downstream
signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading …

Receptor-interacting serine/threonine protein kinase 2 (RIPK2) is an important kinase of the
innate immune system. Herein, we describe the optimization of a series of RIPK2 PROTACs …

RIP1 regulates cell death and inflammation and is believed to play an important role in
contributing to a variety of human pathologies, including immune-mediated inflammatory …

RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway
contributing to a variety of human pathologies, including immune-mediated inflammatory …

This study was conducted to comprehensively evaluate the performance of various allometric
scaling methods for the prediction of human clearance. Allometric scaling was used to …