Many central nervous system (CNS) drug discovery programs require the successful
collection of cerebrospinal fluid (CSF) for assessing CNS penetration and distribution of new …

The 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, more
commonly known as ‘statins’, are a novel class of drugs widely used for the treatment of …

A sensitive high‐performance liquid chromatography–positive ion electrospray tandem mass
spectrometry method was developed and validated for the quantification of sitagliptin, a …

Serotonin (5-HT) plays an important role in the regulation of several basic functions of the
central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT 6 ) …

Organ weight analysis is an important endpoint for identification of potentially harmful effects
of test compounds in toxicology studies. Organ weight differences are often accompanied …

Chemical neurotransmission has been the subject of intensive investigations in recent years.
Acetylcholine is an essential neurotransmitter in the central nervous system as it has an …

INTRODUCTION: The most commonly used Von Frey filaments are productive in evaluating
behavioral responses of neuropathic pain in preclinical and clinical research. To reduce the …

Alzheimer's disease (AD) is a neurodegenerative disease which has a higher prevalence
and incidence in older people. The need for improved AD therapies is unmet. The 5-…

Introduction This study explored the efficacy and safety of a serotonin‐6 receptor antagonist,
masupirdine, as adjunct treatment in patients with moderate Alzheimer's disease (AD) …

A rapid and sensitive liquid chromatography tandem mass spectrometry method for simultaneous
quantification of catecholamine neurotransmitters in microdialysates was developed. …