Tissue water content in rats measured by desiccation

RF Reinoso, BA Telfer, M Rowland - Journal of pharmacological and …, 1997 - Elsevier
Tissue water content was determined by desiccation to constant weight at 40–50C in 14
tissues from two groups of rats weighing 200–250 and 270–430 g, respectively. The water …

Synthesis and Biological Evaluation of a New Series of Hexahydro-2H-pyrano[3,2-c]quinolines as Novel Selective σ1 Receptor Ligands

…, AR Fernandez de Henestrosa… - Journal of Medicinal …, 2013 - ACS Publications
The synthesis and pharmacological activity of a new series of hexahydro-2H-pyrano[3,2-c]quinoline
derivatives as potent σ 1 receptor (σ 1 R) ligands are reported. This family, which …

Discovery and Characterization of 4'-(2-Furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a Potent, Selective, and Efficacious A2B Adenosine Receptor …

…, T Domenech, S Benito, RF Reinoso… - Journal of medicinal …, 2007 - ACS Publications
A novel series of N-heteroaryl 4‘-(2-furyl)-4,5‘-bipyrimidin-2‘-amines has been identified as
potent and selective A 2B adenosine receptor antagonists. In particular, compound 5 showed …

Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties

…, M Porras, S Yeste, RF Reinoso… - Journal of Medicinal …, 2023 - ACS Publications
The synthesis and pharmacological activity of a new series of isoxazolylpyrimidines as
sigma-2 receptor (σ 2 R) ligands are reported. Modification of a new hit retrieved in an HTS …

Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx® and Arcoxia®

F Caturla, M Amat, RF Reinoso, M Córdoba… - Bioorganic & medicinal …, 2006 - Elsevier
The preparation of the sulfoxide analogues 2 and 4, and their enantiomeric pure forms is
discussed as well as their potential to act as prodrugs to the potent and selective sulfone-…

Uptake of teicoplanin by isolated rat hepatocytes: comparison with in vivo hepatic distribution

RF Reinoso, BA Telfer, BS Brennan… - Drug Metabolism and …, 2001 - ASPET
Tissue distribution of teicoplanin, a large glycopeptide antibiotic, is slow but at equilibrium its
whole body distribution volume is relatively large (Vss = 1.18–2.78 liter/kg), despite a high …

Biaryl analogues of teriflunomide as potent DHODH inhibitors

…, I Moreno, J Sanahuja, M Andrés, RF Reinoso… - Bioorganic & medicinal …, 2011 - Elsevier
The structure–activity relationships of a novel series of biaryl dihydroorotate dehydrogenase
(DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the …

Discovery of potent and selective bicyclic A2B adenosine receptor antagonists via bioisosteric amide replacement

…, JA Alonso, A Nueda, T Domenech, RF Reinoso… - Bioorganic & Medicinal …, 2010 - Elsevier
Several new potent and selective A 2B adenosine receptor antagonists have been prepared
in which the aryl–amide moiety of the lead series, exemplified by 1a, has been replaced by …

[HTML][HTML] EST79232 and EST79376, two novel Sigma-1 receptor ligands, exert neuroprotection on models of Motoneuron degeneration

…, N Hernández, S Yeste, RF Reinoso… - International journal of …, 2022 - mdpi.com
Motor neuron diseases (MNDs) include sporadic and hereditary neurological disorders
characterized by progressive degeneration of motor neurons (MNs). Sigma-1 receptor (Sig-1R) …

Pharmacokinetics of E‐6087, a new anti‐inflammatory agent, in rats and dogs

RF Reinoso, R Farrán, T Moragón… - … & drug disposition, 2001 - Wiley Online Library
The pharmacokinetics of E‐6087, a newly developed cyclooxygenase‐2 inhibitor, was
studied in rats and dogs after single oral and intravenous doses. In both animal species, E‐6087 …