Aims The purpose of this in vivo human study was to assess the effect of altered gastric
emptying and gastrointestinal motility on the absorption of metformin in healthy subjects. …

The pharmacokinetics of intravenously administered cefepime (1000 mg over 30 minutes)
were studied in 5 healthy volunteers and 20 patients with various degrees of renal impairment…

The therapeutic implications of chirality in medicinal compounds is now well recognized. 1±3
Indeed, the failure to recognize chirality while describing the drug disposition, including …

The metabolism of irbesartan, a highly selective and potent nonpeptide angiotensin II
receptor antagonist, has been investigated in humans. An aliquot of pooled urine from healthy …

Nefazodone is a new antidepressant drug, chemically unrelated to the tricyclic, tetracyclic or
selective serotonin uptake inhibitors. Nefazodone blocks the serotonin 5-HT 2 receptors and …

This study was conducted to determine the potential for an interaction between nefazodone,
a new antidepressant, and triazolam after a single dose of triazolam and multiple doses of …

Absolute oral bioavailability and disposition characteristics of irbesartan, an angiotensin II
receptor antagonist, were investigated in 18 healthy young male volunteers. Subjects received …

The effect of food on the pharmacokinetics of didanosine was evaluated in an open two‐way
crossover study in eight male subjects who tested seropositive for the human …

Steady state pharmacokinetics, absolute bioavailability, and dose proportionality of cefepime
were evaluated in healthy male subjects after single (250, 500, 1000, or 2000 mg) and …

The effects of age and gender on the pharmacokinetics of cefepime were examined in 48
volunteers following administration of a single 1,000-mg intravenous dose. Male and female …