Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist–deficient mice
R Horai, S Saijo, H Tanioka, S Nakae, K Sudo… - The Journal of …, 2000 - rupress.org
Interleukin (IL)-1 is a proinflammatory cytokine that plays important roles in inflammation,
host defense, and the neuro-immuno-endocrine network. IL-1 receptor antagonist (ra) is an …
host defense, and the neuro-immuno-endocrine network. IL-1 receptor antagonist (ra) is an …
Production of mice deficient in genes for interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 receptor antagonist shows that IL-1β is crucial in turpentine-induced fever …
R Horai, M Asano, K Sudo, H Kanuka… - The Journal of …, 1998 - rupress.org
Interleukin (IL)-1 is a major mediator of inflammation and exerts pleiotropic effects on the
neuro-immuno-endocrine system. To elucidate pathophysiological roles of IL-1, we have first …
neuro-immuno-endocrine system. To elucidate pathophysiological roles of IL-1, we have first …
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
S Nakae, S Saijo, R Horai, K Sudo… - Proceedings of the …, 2003 - National Acad Sciences
IL-17 is a T cell-derived, proinflammatory cytokine that is suspected to be involved in the
development of various inflammatory diseases. Although there are elevated levels of IL-17 in …
development of various inflammatory diseases. Although there are elevated levels of IL-17 in …
Cutting edge: NKT cells constitutively express IL-23 receptor and RORγt and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion
AV Rachitskaya, AM Hansen, R Horai, Z Li… - The Journal of …, 2008 - journals.aai.org
Th17 cells require IL-6 and TGFβ for lineage commitment and IL-23 for maintenance.
Unexpectedly, naive IL-6−/− splenocytes stimulated with anti-CD3 and IL-23 produced normal …
Unexpectedly, naive IL-6−/− splenocytes stimulated with anti-CD3 and IL-23 produced normal …
Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand
K Miwa, M Asano, R Horai, Y Iwakura, S Nagata… - Nature medicine, 1998 - nature.com
Fas ligand is a well-characterized apoptosis inducer. Here we demonstrate that Fas ligand
induces the processing and secretion of interleukin-1β (IL-1β) in peritoneal exudate cells. …
induces the processing and secretion of interleukin-1β (IL-1β) in peritoneal exudate cells. …
[PDF][PDF] Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site
R Horai, CR Zárate-Bladés, P Dillenburg-Pilla, J Chen… - Immunity, 2015 - cell.com
Activated retina-specific T cells that have acquired the ability to break through the blood-retinal
barrier are thought to be causally involved in autoimmune uveitis, a major cause of …
barrier are thought to be causally involved in autoimmune uveitis, a major cause of …
IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
T Matsuki, R Horai, K Sudo, Y Iwakura - The Journal of experimental …, 2003 - rupress.org
IL-1 is a proinflammatory cytokine that plays important roles in inflammation. However, the
role of this cytokine under physiological conditions is not known completely. In this paper, we …
role of this cytokine under physiological conditions is not known completely. In this paper, we …
[HTML][HTML] Protective role of interleukin-1 in mycobacterial infection in IL-1 α/β double-knockout mice
H Yamada, S Mizumo, R Horai, Y Iwakura… - Laboratory …, 2000 - Elsevier
To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in mycobacterial
inflammation, IL-1 α/β double-knockout (KO) mice were produced. These mice were infected …
inflammation, IL-1 α/β double-knockout (KO) mice were produced. These mice were infected …
Six1 controls patterning of the mouse otic vesicle
…, K Kitamura, S Muto, H Kotaki, K Sudo, R Horai… - 2004 - journals.biologists.com
Six1 is a member of the Six family homeobox genes, which function as components of the
Pax-Six-Eya-Dach gene network to control organ development. Six1 is expressed in otic …
Pax-Six-Eya-Dach gene network to control organ development. Six1 is expressed in otic …
Cytokines in autoimmune uveitis
R Horai, RR Caspi - Journal of Interferon & Cytokine Research, 2011 - liebertpub.com
Autoimmune uveitis is a complex group of sight-threatening diseases that arise without a
known infectious trigger. The disorder is often associated with immunological responses to …
known infectious trigger. The disorder is often associated with immunological responses to …