Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
MD Burke, S Thompson, RJ Weaver, CR Wolf… - Biochemical …, 1994 - Elsevier
The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes
for measuring the cytochrome P450 forms, CYP1A1 and CYP2B1, respectively, and their …
for measuring the cytochrome P450 forms, CYP1A1 and CYP2B1, respectively, and their …
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier
S Dauchy, F Dutheil, RJ Weaver… - Journal of …, 2008 - Wiley Online Library
We have established the expression patterns of the genes encoding ATP‐binding cassette (ABC)
transporters and cytochromes P450 (CYPs) at the adult human blood–brain barrier (…
transporters and cytochromes P450 (CYPs) at the adult human blood–brain barrier (…
[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry
…, JP Valentin, F Van Goethem, RJ Weaver… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety margins for …
treatment-related effects were carefully reported and used as a basis to calculate safety margins for …
Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells
S Dauchy, F Miller, PO Couraud, RJ Weaver… - Biochemical …, 2009 - Elsevier
We investigated the expression of genes encoding ABC transporters, cytochromes P450 (CYPs)
and some transcription factors in the hCMEC/D3 immortalized human cerebral …
and some transcription factors in the hCMEC/D3 immortalized human cerebral …
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological
process that cannot yet be recapitulated in a single in vitro model. Current preclinical …
process that cannot yet be recapitulated in a single in vitro model. Current preclinical …
[HTML][HTML] Challenges and approaches for the development of safer immunomodulatory biologics
…, MD Todd, JW Van Der Laan, RJ Weaver… - Nature Reviews Drug …, 2013 - nature.com
Immunomodulatory biologics, which render their therapeutic effects by modulating or harnessing
immune responses, have proven their therapeutic utility in several complex conditions …
immune responses, have proven their therapeutic utility in several complex conditions …
ALMA Lensing Cluster Survey: Hubble Space Telescope and Spitzer Photometry of 33 Lensed Fields Built with CHArGE
We present a set of multiwavelength mosaics and photometric catalogs in the Atacama Large
Millimeter/submillimeter Array (ALMA) lensing cluster survey fields. The catalogs were built …
Millimeter/submillimeter Array (ALMA) lensing cluster survey fields. The catalogs were built …
[HTML][HTML] A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge
for the pharmaceutical industry. We therefore determined whether cell models currently …
for the pharmaceutical industry. We therefore determined whether cell models currently …
Today's challenges to de-risk and predict drug safety in human “mind-the-gap”
RJ Weaver, JP Valentin - Toxicological Sciences, 2019 - academic.oup.com
Current gaps in drug safety sciences can result from the inability (1) to identify hazard
across multiple target organs, (2) to predict and risk assess with certainty against drug safety …
across multiple target organs, (2) to predict and risk assess with certainty against drug safety …
Comparative proteomic characterization of 4 human liver-derived single cell culture models reveals significant variation in the capacity for drug disposition …
…, L Richert, H Aerts, RJ Weaver… - Toxicological …, 2015 - academic.oup.com
In vitro preclinical models for the assessment of drug-induced liver injury (DILI) are usually
based on cryopreserved primary human hepatocytes (cPHH) or human hepatic tumor-derived …
based on cryopreserved primary human hepatocytes (cPHH) or human hepatic tumor-derived …