User profiles for Richard N. Upton
 | Richard UptonUniversity of South Australia Verified email at unisa.edu.au Cited by 7171 |
Food, gastrointestinal pH, and models of oral drug absorption
AY Abuhelwa, DB Williams, RN Upton… - European journal of …, 2017 - Elsevier
This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …
Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema: an MRI study
Background Left ventricular (LV) filling is impaired in patients with severe emphysema
manifesting in small end-diastolic dimensions. We hypothesized that the hyperinflated lungs of …
manifesting in small end-diastolic dimensions. We hypothesized that the hyperinflated lungs of …
The performance of compartmental and physiologically based recirculatory pharmacokinetic models for propofol: a comparison using bolus, continuous, and target …
BACKGROUND: With the growing use of pharmacokinetic (PK)-driven drug delivery and/or
drug advisory displays, identifying the PK model that best characterizes propofol plasma …
drug advisory displays, identifying the PK model that best characterizes propofol plasma …
Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration
Indicator dilution theory predicts that the first-pass pulmonary and systemic arterial
concentrations of a drug will be inversely related to the cardiac output. For high-clearance drugs, …
concentrations of a drug will be inversely related to the cardiac output. For high-clearance drugs, …
A quantitative review and meta-models of the variability and factors affecting oral drug absorption—part I: gastrointestinal pH
This study aimed to conduct a quantitative meta-analysis for the values of, and variability in,
gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the …
gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the …
Population pharmacokinetic modeling of itraconazole and hydroxyitraconazole for oral SUBA-itraconazole and sporanox capsule formulations in healthy subjects in …
…, S Mudge, D Hayes, RN Upton - Antimicrobial agents …, 2015 - Am Soc Microbiol
Itraconazole is an orally active antifungal agent that has complex and highly variable
absorption kinetics that is highly affected by food. This study aimed to develop a population …
absorption kinetics that is highly affected by food. This study aimed to develop a population …
Pharmacokinetic optimisation of opioid treatment in acute pain therapy
RN Upton, TJ Semple, PE Macintyre - Clinical pharmacokinetics, 1997 - Springer
Traditionally, opioids have been administered as fixed doses at fixed dose intervals. This
approach has been largely ineffective. Patient-controlled analgesia (PCA) and upgraded …
approach has been largely ineffective. Patient-controlled analgesia (PCA) and upgraded …
Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling
RN Upton - Journal of pharmacological and toxicological methods, 2008 - Elsevier
INTRODUCTION: Physiological approaches to pharmacokinetic analysis require data on
organ sizes and organ blood flows for a given species. An internally consistent compilation of …
organ sizes and organ blood flows for a given species. An internally consistent compilation of …
Hemodynamic and central nervous system effects of intravenous bolus doses of lidocaine, bupivacaine, and ropivacaine in sheep
…, AH Ilsley, WB Runciman, RN Upton - Anesthesia & …, 1989 - journals.lww.com
Lidocaine hydrochloride (HCI)(80–320 mg), bupivacaine HCl (20–80 mg), and ropivacaine
HO (30–120 mg) were administered as intravenous bolus doses to conscious sheep (n= 18; …
HO (30–120 mg) were administered as intravenous bolus doses to conscious sheep (n= 18; …
A quantitative review and meta-models of the variability and factors affecting oral drug absorption—part II: gastrointestinal transit time
This study aimed to conduct a quantitative meta-analysis for the values of, and variability in,
gastrointestinal (GI) transit times of non-disintegrating single-unit (“tablet”) and multiple-unit (“…
gastrointestinal (GI) transit times of non-disintegrating single-unit (“tablet”) and multiple-unit (“…