Human African trypanosomiasis: pharmacological re‐engagement with a neglected disease
…, DW Boykin, R Brun, RR Tidwell - British journal of …, 2007 - Wiley Online Library
This review discusses the challenges of chemotherapy for human African trypanosomiasis (HAT).
The few drugs registered for use against the disease are unsatisfactory for a number of …
The few drugs registered for use against the disease are unsatisfactory for a number of …
Structure, DNA minor groove binding, and base pair specificity of alkyl-and aryl-linked bis (amidinobenzimidazoles) and bis (amidinoindoles)
TA Fairley, RR Tidwell, I Donkor… - Journal of medicinal …, 1993 - ACS Publications
A series of bis (amidinobenzimidazoles) and bis (amidinoindoles) with varied linking chains
connecting the aromatic groups and various modifications to the basic amidino groups have …
connecting the aromatic groups and various modifications to the basic amidino groups have …
Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents
…, CC Dykstra, S Jones, RR Tidwell… - Antimicrobial agents …, 1998 - Am Soc Microbiol
Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic
substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities …
substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities …
Extended Aromatic Furan Amidino Derivatives as Anti-Pneumocystis carinii Agents
…, DR McCurdy, JE Hall, RR Tidwell… - Journal of medicinal …, 1998 - ACS Publications
The syntheses of nine new derivatives of 2,5-bis[4-(N-alkylamidino)phenyl]furans with
extended aromatic systems are reported. The interaction of these dicationic furans with poly(dA)*…
extended aromatic systems are reported. The interaction of these dicationic furans with poly(dA)*…
Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles
…, KA Werbovetz, R Brun, RR Tidwell - Journal of medicinal …, 2010 - ACS Publications
Novel dicationic triazoles 1−60 were synthesized by the Pinner method from the corresponding
dinitriles, prepared via the copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC). The …
dinitriles, prepared via the copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC). The …
Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections
…, K Ramachandran, RR Tidwell… - Journal of medicinal …, 1996 - ACS Publications
Considerable evidence now indicates that DNA is the receptor site for dicationic benzimidazole
anti-opportunistic infections agents (Bell, CA; Dykstra, CC; Naiman, NAI; Cory, M.; Fairley…
anti-opportunistic infections agents (Bell, CA; Dykstra, CC; Naiman, NAI; Cory, M.; Fairley…
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289
…, MA Ismail, JE Hall, RR Tidwell, R Brun - Antimicrobial agents …, 2009 - Am Soc Microbiol
African sleeping sickness is a fatal parasitic disease, and all drugs currently in use for
treatment have strong liabilities. It is essential to find new, effective, and less toxic drugs, ideally …
treatment have strong liabilities. It is essential to find new, effective, and less toxic drugs, ideally …
Dicationic DNA minor groove binders as antimicrobial agents
RR Tidwell, DW Boykin - Small molecule DNA and RNA binders …, 2002 - Wiley Online Library
DNA is an attractive target for drug design due to the large amount of detailed structural
information and its role as the source of genetic information [1]. The strategy of using small …
information and its role as the source of genetic information [1]. The strategy of using small …
2,4-Diphenyl Furan Diamidines as Novel Anti-Pneumocystis carinii Pneumonia Agents
…, JE Hall, BC Bender, RR Tidwell… - Journal of medicinal …, 1999 - ACS Publications
Dicationic 2,4-bis(4-amidinophenyl)furans 5−10 and 2,4-bis(4-amidinophenyl)-3,5-dimethylfurans
14 and 15 have been synthesized. Thermal melting studies revealed high binding …
14 and 15 have been synthesized. Thermal melting studies revealed high binding …
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes
…, MA Ismail, DW Boykin, RR Tidwell… - Antimicrobial agents …, 2006 - Am Soc Microbiol
The aromatic diamidine pentamidine has long been used to treat early-stage human African
trypanosomiasis (HAT). Two analogs of pentamidine, DB75 and DB820, have been shown …
trypanosomiasis (HAT). Two analogs of pentamidine, DB75 and DB820, have been shown …