Both eucaryotic and procaryotic cells are resistant to a large number of antibiotics because
of the activities of export transporters. The most studied transporter in the mammalian ATP-…

The objectives of this study were to assess the safety, pharmacokinetics, and efficacy of
pegylated interferon alfa‐2b (PEG‐Intron) plus ribavirin in patients with chronic hepatitis C. A …

Purpose. HMG-CoA reductase inhibitors (statins) are commonly prescribed for lipid lowering
to treat hypercholesterolemia. Although they are well tolerated, their pharmacokinetic …

[ 3 H]Loratadine was incubated with human liver microsomes to determine which cytochrome
P450 (CYP) enzymes are responsible for its oxidative metabolism. Specific enzymes were …

These studies were conducted to assess the systemic bioavailability of mometasone furoate
(MF) administered by both the dry‐powder inhaler (DPI) and the metered‐dose inhaler with …

Background No large trials have been done to investigate the efficacy of an intervention
combining a specific compound and several lifestyle interventions compared with placebo for …

There is wide acknowledgement that apathy is an important behavioural syndrome in
Alzheimer’s disease and in various neuropsychiatric disorders. In light of recent research and the …

The cytochrome P450 enzyme family is one of the major drug metabolizing systems in man.
2. Factors such as age, gender, race, environment, and drug treatment may have …

Purpose. The grapefruit juice component bergamottin is known to inactivate cytochrome P450
3A4, with grapefruit juice consumption causing increased absorption and enhanced oral …

With P-glycoprotein (P-gp) continuing to have prominence among the ABC transporters for
its ability to remove various xenobiotics from many cell types, accurate and robust methods …