Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and …

D Yang, RE Pearce, X Wang, R Gaedigk… - Biochemical …, 2009 - Elsevier
Carboxylesterases hydrolyze chemicals containing such functional groups as a carboxylic
acid ester, amide and thioester. The liver contains the highest carboxylesterase activity and …

A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma

…, L Avila, T Mariani, R Gaedigk… - American journal of …, 2010 - atsjournals.org
Rationale: Animal models demonstrate that aberrant gene expression in utero can result in
abnormal pulmonary phenotypes. Objectives: We sought to identify genes that are …

PharmGKB summary: methotrexate pathway

…, K Giacomini, ML Becker, R Gaedigk… - Pharmacogenetics …, 2011 - journals.lww.com
Methotrexate is a folate analog that is used in the treatment of cancers (eg acute lymphoblastic
leukemia, non-Hodgkin lymphoma, osteosarcoma, and colon cancer) and autoimmune …

Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters

…, BAE De Koning, JS Leeder, R Gaedigk… - Drug Metabolism and …, 2014 - ASPET
Many drugs prescribed to children are drug transporter substrates. Drug transporters are
membrane-bound proteins that mediate the cellular uptake or efflux of drugs and are important …

Ontogeny of hepatic drug transporters as quantified by LC‐MS/MS proteomics

…, A Gaedigk, M Vrana, R Gaedigk… - Clinical …, 2016 - Wiley Online Library
Protein expression of major hepatic uptake and efflux drug transporters in human pediatric (n
= 69) and adult (n = 41) livers was quantified by liquid chromatography / tandem mass …

Variability of CYP3A7 expression in human fetal liver

JS Leeder, R Gaedigk, KA Marcucci, A Gaedigk… - … of Pharmacology and …, 2005 - ASPET
Fetal liver CYP3A7 plays an important role in placental estriol synthesis during pregnancy,
yet little is known concerning the extent or consequences of variability in expression. The …

Age‐and genotype‐dependent variability in the protein abundance and activity of six major uridine diphosphate‐glucuronosyltransferases in human liver

DK Bhatt, A Mehrotra, A Gaedigk… - Clinical …, 2019 - Wiley Online Library
The ontogeny of hepatic uridine diphosphate‐glucuronosyltransferases (UGTs) was investigated
by determining their protein abundance in human liver microsomes isolated from 136 …

Transcriptomic analysis of human lung development

…, KG Tantisira, VJ Carey, R Gaedigk… - American journal of …, 2010 - atsjournals.org
Rationale: Current understanding of the molecular regulation of lung development is limited
and derives mostly from animal studies. Objectives: To define global patterns of gene …

Fetal lung and placental methylation is associated with in utero nicotine exposure

D Chhabra, S Sharma, AT Kho, R Gaedigk… - Epigenetics, 2014 - Taylor & Francis
In utero smoke exposure has been shown to have detrimental effects on lung function and
to be associated with persistent wheezing and asthma in children. One potential mechanism …

[HTML][HTML] Vitamin D related genes in lung development and asthma pathogenesis

AT Kho, S Sharma, W Qiu, R Gaedigk… - BMC medical …, 2013 - Springer
Background Poor maternal vitamin D intake is a risk factor for subsequent childhood asthma,
suggesting that in utero changes related to vitamin D responsive genes might play a crucial …