Cerivastatin: pharmacology of a novel synthetic and highly active HMG-CoA reductase inhibitor
H Bischoff, R Angerbauer, J Bender, E Bischoff… - Atherosclerosis, 1997 - Elsevier
The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure
inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin …
inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin …
Metabolism of cerivastatin by human liver microsomes in vitro: characterization of primary metabolic pathways and of cytochrome P450 isozymes involved
M Boberg, R Angerbauer, P Fey, WK Kanhai… - Drug metabolism and …, 1997 - ASPET
Biotransformation of cerivastatin, a new cholesterol-lowering drug, by human liver microsomes
was investigated using the 14 C-labeled drug. Metabolite profiles were established by …
was investigated using the 14 C-labeled drug. Metabolite profiles were established by …
Biotransformation of Cerivastatin in Mice, Rats, and Dogsin vivo
M Boberg, R Angerbauer, WK Kanhai, W Karl… - Drug Metabolism and …, 1998 - ASPET
Biotransformation of cerivastatin was investigated in mice, rats, and dogs in vivo using the
14 C-labeled drug. Marked species differences exist, both in pathways and extent of …
14 C-labeled drug. Marked species differences exist, both in pathways and extent of …
Synthesis and glycosidation reactions of acetylated racemic pseudoglycals1
R Angerbauer, RR Schmidt - Carbohydrate Research, 1981 - Elsevier
The Diels-Alder reaction of 1,3-butadienylene diacetate with activated carbonyl compounds
yields O-acetylated pseudoglycals (hex-2-enopyranoses). These reactive compounds are …
yields O-acetylated pseudoglycals (hex-2-enopyranoses). These reactive compounds are …
Synthesis of [14C]Cerivastatin
M Radtke, R Angerbauer - Journal of Labelled Compounds and …, 1999 - Wiley Online Library
The title compound [ 14 C]Cerivastatin ([ 14 C]]BAY w 6228) was synthesized in order to
introduce the label into the metabolically stable 7‐position of the side chain. Convergent …
introduce the label into the metabolically stable 7‐position of the side chain. Convergent …
[CITATION][C] A convenient preparation of 2, 3-unsaturated N-galactosyl derivatives
RR Schmidt, R Angerbauer - Carbohydrate Research, 1979 - Elsevier
Pseudoglycals (hex-2-enopyranoses) are valuable intermediates for the synthesis of
modified carbohydrates, glycosides, and oligosaccharides’-3. 2, 3-Dideoxy-cr-IX-er~~ hro-and-t/…
modified carbohydrates, glycosides, and oligosaccharides’-3. 2, 3-Dideoxy-cr-IX-er~~ hro-and-t/…
[CITATION][C] Simple de‐novo Synthesis of Reactive Pseudoglycals (Hex‐2‐enopyranosides)—Stereospecific α‐Glycoside Coupling
RR Schmidt, R Angerbauer - … Chemie International Edition in …, 1977 - Wiley Online Library
The unsaturated sugar derivatives (1) and (2), R Ac, are readily accessible via the
indicated route.(1), R Ac, is conveniently transformed by alcohols into the formerly difficultly …
indicated route.(1), R Ac, is conveniently transformed by alcohols into the formerly difficultly …
[CITATION][C] A short synthesis of racemic uronic acids and 2, 3-anhydrouronic acids
RR Schmidt, R Angerbauer - Carbohydrate Research, 1981 - Elsevier
The Duels-Alder reactlon of tlmls-trmrv-I 3-butadlenylene dwzetatc wth nctw&zd carbony!
compounds yields IO-acetylpseudoglycals(hex-2-enopyranoses) which are mtermedlates for …
compounds yields IO-acetylpseudoglycals(hex-2-enopyranoses) which are mtermedlates for …
[CITATION][C] A New Entry to Naphthalene Oxides
RR Schmidt, R Angerbauer - … Chemie International Edition in …, 1979 - Wiley Online Library
A New Entry to Naphthalene Oxides<link href='#fn1'></link><link href='#fn2'></link> Page 1
The production of ultrafine powders by chemical vapor deposition could lead to a …
The production of ultrafine powders by chemical vapor deposition could lead to a …
History of drug discovery
JJ Li - Drug Discovery: Practices, Processes, and …, 2013 - books.google.com
… Cerivastatin (Baycol) was discovered by Bayer scientists led by medicinal chemist Rolf
Angerbauer and biologist Hilmar Bischoff in the late 1980s. It was on the market in 1997 but was …
Angerbauer and biologist Hilmar Bischoff in the late 1980s. It was on the market in 1997 but was …