Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have shown …

Objective: To review the present status of bioartificial liver (BAL) devices and their obtained
clinical results. Background: Acute liver failure (ALF) is a disease with a high mortality. …

Background and Aims The gap between patients on transplant waiting lists and available
donor organs is steadily increasing. Human organoids derived from leucine‐rich repeat‐…

For bioartificial liver application, cells should meet the following minimal requirements:
ammonia elimination, drug metabolism and blood protein synthesis. Here we explore the …

Haemonchus contortus is a sheep parasitic nematode that causes severe economic losses.
Previous studies have indicated a high degree of genetic heterogeneity, which is hardly …

Anno 2004 freshly isolated or cryopreserved porcine or human hepatocytes have been most
frequently used as biocomponent in clinically applied bioartificial livers (BALs). Phase 1 …

A major roadblock to the application of bioartificial livers is the need for a human liver cell
line that displays a high and broad level of hepatic functionality. The human bipotent liver …

Background A clonal cell line that combines both stable hepatic function and proliferation
capacity is desirable for in vitro applications that depend on hepatic function, such as …

Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative
human hepatocyte cell source have started. There are two cell lines that are currently in an …

Introduction: Bioartificial livers (BALs) were originally developed to treat patients suffering
from severe liver failure and relied on primary hepatocytes or on hepatoblastoma-derived cell …